Use of MEK1 inhibitors as protective agents against damage due t

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 3135

Patent

active

061504017

ABSTRACT:
The invention relates to the use of MEK1 inhibitors to reduce tissue damage resulting from ischemia and/or reperfusion, particularly brain damage associated with ischemia resulting from stroke. Pharmaceutical compositions, kits and perfusion fluids including MEK1 inhibitors are also provided.

REFERENCES:
patent: 5459144 (1995-10-01), Girijavallabhan et al.
patent: 5525625 (1996-06-01), Bridges et al.
patent: 5633237 (1997-05-01), Hansen, Jr. et al.
patent: 5717100 (1998-02-01), Selnick et al.
patent: 5849733 (1998-12-01), Kim
Bederson et al., Stroke 17:1304-1308, 1986.
Uemura et al., Brain Res. 542:343-347, 1991.
Hu et al., J. Neurochemistry 62:1357-1367, 1994.
Huang et al., Science 265:1883-1885, 1994.
Seko et al., Circ. Res. 78:82-90, 1996.
Aikawa et al., J. Biol. Chem. 100:1813-1821, 1997.
Muller et al., J. Biol. Chem. 272:23435-23439, 1997.
Kindy, J. Cer. Blood Flow and Metab. 13:372-377, 1993.
Namura et al., Stroke 29:326(P142), Jan. 1998.
Mizukami et al., Biochem. J. 323:785-790, 1997.
Dufourney et al., J. of Biol. Chem. 272(49):31163-31171, Dec. 5, 1997.

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