Use of mannosamine derivatives for the stimulation of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S023000, C536S004100

Reexamination Certificate

active

10490934

ABSTRACT:
The present invention relates to the use of peracylated N-acyl-mannosamine derivatives for the preparation of a medicament for stimulating neurite growth.

REFERENCES:
patent: 6274568 (2001-08-01), Schnaar et al.
patent: 19738484 (1999-04-01), None
patent: WO 00/07602 (2000-02-01), None
patent: WO 00/29567 (2000-05-01), None
Charter et al. “Differential effects of unnatural sialic acids on the polysialylation of the neural cell adhesion molecule and neuronal behavior,” J. Biol. Chem. 277(11) 9255-9261 (2002).
Ogiso et al. “Lack of cell density-dependent changes in gangliosides of rat primary culture neurons,” Dev. Neuroscience 14(3) 247-255 (1992).
Grünholz et al., “Inhibition of in vitro biosynthesis of N-acetylneuraminic acid by n-acyl-and n-alkyl-2-amino-2-dexyhexoses” Carbohydrate Research, 96:259-270 (1981).
Kayser et al., “Incorporation of N-acyl-2-amino-2deoxy-hexoses into glycosphingolipids of the pheochromocytoma cell lin PC 12,” FEBS 301(2):137-140 (1992).
Schauer et al., “Biochemistry and role of sialic acids,” Biology of the sialic acids, Rosenberg (ed.) Plenum Press, New York, 1995.
Varki, “Mini Review-Diversity in the sialic acids,” Glycobiology 2(1):25-40 (1992).

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