Use of male essence to alter female endocrine response

Chemistry: analytical and immunological testing – Pregnancy or ovulation

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

436128, 436131, 436906, 436817, 514169, 514170, 514177, 514178, 514179, 514182, G01N 3348, G01N 3350

Patent

active

051550458

ABSTRACT:
A novel method for treating a human female is disclosed comprising the step of exposing the nasal region of said female to at least a portion of the axillary secretions of a human male. This exposure is preferably continued in amounts and for a duration which are effective to significantly alter an endocrine related characteristic, such as the menstrual cycle length, of that female. In particular, the portions of male axillary secretions to be exposed to the female preferably comprise one or more compounds such as androstenol, dehydroepiandrosterone, and/or a compound or compounds exhibiting a burnt heavy axiallary-like odor which elutes at about 50 minutes as shown on the FID response curve of FIG. 3B. Studies show that pooled male donor secretions are effective to alter aberrant menstrual cycles, particularly those exhibiting luteal phase defects such that they become presumptively fertile menstrual cycles having durations of about 29.5.+-.3 days. Symptoms of perimenopause, such as hot flashes, night sweats and irregular menstrual cycles, are also treatable using the methods of this invention, which tend to promote female endocrine regularity and longevity.

REFERENCES:
patent: 3986494 (1976-10-01), Preti et al.
patent: 4010738 (1977-03-01), Preti et al.
patent: 4119089 (1978-10-01), Preti et al.
patent: 4385125 (1983-05-01), Preti et al.
patent: 4670401 (1987-06-01), Cutler et al.
The Merck Index, 10th ed., p. 666 (1983).
Stedman's Medical Dictionary, 24th ed. Williams and Wilkins, Baltimore, 1982, p. 66.
Astwood in The Pharmaceutical Basis of Therapeutics, Edited by Goodman and Gilman, 3rd ed., The Macmillan Co., N.Y. 1965, p. 1576.
R. F. Vollman, "The Degree of Variability of the Length of the Menstrual Cycle in Correlation with Age of Woman", Gynaecologia 142(5):310-314 (Nov. 1956).
M. K. McClintock, "Pheromonal Regulation of the Ovarian Cycle: Enhancement, Suppression and Synchrony", Pheromones and Reproduction in Mammals, Edited by J. G. Vandenbergh New York, Academic Press, pp. 113-149 (1983).
M. K. McClintock, "Estrous Synchrony: Modulation of Ovarian Cycle Length by Female Pheromones", Physiol. Behav., 32:701-705 (1984).
M. K. Izard, "Phermones and Reproduction in Domestic Animals", Pheromones and Reproduction in Mammals, edited by J. G. Vandenbergh New York, Academic Press, pp. 253-281 (1983).
Izard et al, "Priming Pheromones From Oestrous Cows Increase Synchronization of Oestrus in Dairy Heifers After PGF-2.alpha.Injection", Reproduction Fertility, 66:189-196 (1982).
M. K. McClintock, "Menstrual Synchrony and Suppression", Nature, 229:244-245 (Jan., 22, 1971).
C. A. Graham et al "Menstrual Synchrony in Female Undergraduates Living on a Coeducational Campus", Psychoneuroendocrinology, 5:245-252 (1980).
Rogel, "A Critical Evaluation of the Possibility of Higher Primate Reproductive and Sexual Pheromones" , Psychol. Bull. 85:810-830, (1978).
D. M. Quadagno, "Influence of Male Social Contacts, Exercise and All-Female Living Conditions on the Menstrual Cycle" Psychoneuroendrocrinology, 6:239-244 (1981).
J. L. Veith et al, "Exposure to Men Influences in the Occurrence of Ovulation in Women", Physiology & Behavior, 31:313-315 (1983).
Russell et al "Olfactory Influences on the Human Menstrual Cycle", Pharmac. Biochem. Behav., 13(5):1-2 (1980).
J. N. Labows, "Human Odors--What Can They Tell Us?38 , Perfumer and Flavorist, 4:12-17 (1979).
J. J. Leyden et al. al "The Microbiology of the Human Axilla and Its Relation to Axillary Odors", J. Invest. Dermatol. 77:413-416.
S. Bird et al, "Axillary 5.alpha.androst-16-en-3-one, Cholesterol and Squalene in Men; Preliminary Evidence for 5.alpha.androst-16-3n-3-one Being a Product of Bacterial Action", J. Steroid Biochem., 17:517-522 (1982).
S. Bird et al, "Measurement of 5.alpha.androst-16-en-one in Human Axillary Secretions by Radioimmunoassay", J. Endrocrinol., 85:80-90.
B. W. L. Brooksbank et al, "The Dectection of 5.alpha.androst-16-en-3.alpha.ol in Human Male Axillary Sweat", Experientia, 30:864-865 (1974).
R. V. Vollman, The Menstrual Cycle, vol. 7, (Major Problems in Obstetrics and Gynecology), edited by Emmanuel Freidman, M.D.
A. E. Treloar, "Variation of the Human Menstrual Cycle Through Reproductive Life", Internl Journl Journl of Fert., 12(1):77-126 (1967).
W. Cutler, "Lunar and Menstrual Phase Locking", American Journal of Obstetrics and Gynecology, 137:834 (1980).
W. Cutler et al, "Infertility and Age at First Coitus: A Possible Relationship" J. Biosoc. Sc., 11:425-432 (1979).
W. Cutler et al, "Sexual Behavior Frequency and Menstrual Cycle Length in Mature Premenopausal Women", Psychoneuroendocrinology 4:297-309 (1979).
W. Cutler et al, "Luteal Phase Defects: A Possible Relationship Between Short Hyperthermic Phase and Sporadic Sexual Behavior in Women", Hormones and Behavior, 13:214-218 (1979).
W. Cutler et al, "Sporadic Sexual Behavior and Menstrual Cycle Length in Women", Hormones and Behavior, 14:163-172 (1980).
W. Cutler et al. al, "The Psychoneuroendocrinology of the Ovulatory Cycle of Woman: A Review", Psychoneuroendocrinology, 5:89 (1980).
W. Cutler et al, "Sexual Behavior, Steroids & Hot Flashes are Associated During the Perimenopause", Neuroendocrinology Letters, 5:185 (1983).
J. N. Labows et al, "Steroid Analysis of Human Apocrine Secretion", Steroids, 34:249-258 (1979).
G. Preti et al, "Cyclic Changes in Volatile Acidic Metabolites of Human Vaginal Secretions and Their Relationships to Ovulation", J. Chem. Ecol., 1:361-376 (1975).
Frolich et al, "Serum Levels of Unconjugated Aetiocholanolone, Androstenedione, Testosterone, Dehydroepiandrosterone, Aldosterone, Progeseterone and Oestrogens During the Normal Menstrual Cycle", Acta Endocrinologica, 81:548-562 (1976).
Abstract presented at the CRB Conference on Reproductive Behavior Jun. 10-12, 1984 at the University of Pittsburgh, entitled "Sex Frequency and Human Axillary Secretion Influence Fertile-Type Menstrual Cycles".
"Male Extract and Heterosexual Behavior Normalize the Menstrual Cycle of Women", Abstract, International Academy of Sex Cambridge, England (Sep., 1984), Cutler et al.
A. R. Genazzani et al, "Possible Correlation Between Plasma Androgen Variations During the Menstrual Cycle and Sexual Behavior in the Human Female", Chemical Abstracts, vol. 91, 1978, Abstract No. 91:121339e, Proc. Serono Symp. 22 (Clin. Psychoneuroendo. Reprod. 419-435.
N. McCoy et al, "Relationships Among Sexual Behavior, Hot Flashes, and Harmone Levels in Perimenopausal Women", Archives of Sexual Behavior, 14(5):385-394 (1985).
Cutler et al, "The Medical Management of Menopause and Premenopause", Chapter 3, J. B. Lippincott Company, pp. 92-121 (1984).
"New Nose to Aid Fertility", Daily News, Oct., 1984.
Bahn, Basic Medical Statistics, Chapter 8, "Review of the Decision Making Process; the Error Risks", p. 86, (1972) Grune & Stratton, Inc.
Cutler et al, "Sexual Behavior and Steroid Levels Among Gynecologically Mature Premenopausal Women", Fertil. & Steril, Apr., 1986.
Cutler et al, "Perimenopausal Sexuality", Archives of Sexual Behavior (in press).
C. C. Norris, "The Menopause", American Journal of Obstet., 41:203-215 (1910).
Metcalf, "Incidence of Ovulatory Cycles in Women Approaching the Menopause", Journal of Biosoc. Sci., 11:39-48 (1979).
Rutherford, "The Menopause", N.Z. Med. J., 87:251-253 (1978).
Kupperman et al, "Contemporary Theory of the Menopausal Syndrome", JAMA 171:1627-1637 (1959).
McCoy et al, "A Longitudinal Study of the Effects of Menopause on Sexuality", Maturitas 7:203-210 (1985).
Treloar, "Menstrual Cyclicity and the Premenopause", Maturitas, 3:249-264 (1981).
A Textbook of Medicine, edited by Cecil, 5th ed., W B Saunders Co., Philadelphia, 1941, pp. 673-675.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of male essence to alter female endocrine response does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of male essence to alter female endocrine response, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of male essence to alter female endocrine response will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1299999

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.