Use of macrolide antibiotics for nonsurgical female sterilizatio

Details Use of macrolide antibiotics for nonsurgical female sterilizatio Use of macrolide antibiotics for nonsurgical female sterilizatio

1997-04-04

1999-03-23

Levy, Neil S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Biocides; animal or insect repellents or attractants

424408, 424422, 424430, 424433, 424489, 514 29, 514 30, A01N 2500

Patent

active

058856013

ABSTRACT:
The present invention relates to a method of female sterilization including delivery of a macrolide antibiotic or a pharmacologically acceptable salt of a macrolide antibiotic to the uterine cavity or fallopian tube of the female. The present invention also relates to a method of endometrial ablation including delivery of a macrolide antibiotic or a pharmacologically acceptable salt of a macrolide antibiotic to the uterine cavity of a female. The endometrial ablation effected in this manner may be used to treat the conditions of excessive menstrual bleeding or menstrual pain in women. A preferred macrolide antibiotic is erythromycin, or its pharmacologically acceptable salts.

REFERENCES:
patent: 4158050 (1979-06-01), Zipper
patent: 4185618 (1980-01-01), Corey
patent: 5095917 (1992-03-01), Vancaillie
Paul Carvalho et al., "Effects of Erythromycin on the Rabbit Pleura: Its Potential Role as a Pleural Sclerosant," Am. J. Respir Crit Case Med., vol. 151, pp. 1228-1232 (1995).
A.A. Joseph et al., "Toxic and antifertility effects of quinacrine hydrochloride in rats," Amer. J. Obst. and Gynecology, vol. 119, pp. 978-981 (1974).
Raymond W. KE et al., "Endometrial ablation to control excessive uterine bleeding," Human Reprod., vol. 6, No. 4, pp. 574-579, (1991).
J. Zipper et al., "The Clinical Efficacy of the Repeated Transcervical Instillation of Quinacrine for Female Sterilization," Int. J. Cynaecol. Obstet., 14:499-502 (1976).
Dusanka Radivojevic et al., "The Effect of Erythromycin on Fertility of Female Mice and Survival of Their Fetuses", Genetika, vol. 11, No. 1, pp. 41-44 (1979).
Katz et al., "Fertility in Adolescent Women Previously Treated for Genitourinary Chlamydial Infection", Adolescent PediatricGynecology, vol. 7, No. 3, pp. 147-152 (1994).

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