Use of macroglobulins to improve the signal-to-background ratio

Details Use of macroglobulins to improve the signal-to-background ratio Use of macroglobulins to improve the signal-to-background ratio

1992-04-30

1994-01-18

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 792, 435 793, 435 23, 435971, 436538, C12Q 168, C12Q 137, G01N 33535, G01N 33537

Patent

active

052799379

ABSTRACT:
A macroglobulin is used to improve the signal-to-background ratio in an affinity binding assay employing a proteinase (or precursor) as a label. The macroglobulin entraps unbound labeled reagent, thereby reducing its signal generating activity, relative to that of the affinity complex.

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