Use of low-molecular-weight highly sulfated polysaccharide...

Details Use of low-molecular-weight highly sulfated polysaccharide... Use of low-molecular-weight highly sulfated polysaccharide...

2005-06-06

2010-11-16

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S123100

Reexamination Certificate

active

07833990

ABSTRACT:
The invention relates to the use of certain low-molecular weight highly sulphated polysaccharide derivatives obtained from a bacterial polysaccharide for preparing a pharmaceutical composition suitable for modulating angiogenesis, particularly for use in accelerating vascular endothelial repair with a low haemorrhage risk in the event of thrombotic injuries.

REFERENCES:
patent: 5985330 (1999-11-01), Collin
patent: 6255296 (2001-07-01), Daniels
patent: 6545145 (2003-04-01), Rougeaux et al.
patent: 6828307 (2004-12-01), Colliec-Jouault et al.
patent: 2005/0245736 (2005-11-01), Oreste et al.
patent: 2005/0256079 (2005-11-01), Oreste et al.
patent: 2006/0014718 (2006-01-01), Oreste et al.
patent: 0221977 (1987-05-01), None
patent: 2701488 (1994-08-01), None
patent: 2755142 (1998-04-01), None
patent: 10 218902 (1998-08-01), None
Guezennec et al , Carbohydrate Polymers, 1999, 37, 19-24.
Zhu, W.H. et al, American Journal of Pathology, 2002, 161 (3), 823-30.
Matou et al, Thrombosis Research, 2002, 106, 213-221.
Luyt et al, The Journal of Pharmacology and Experimental Therapeutics, 2003, 305(1), 24-39.
Aymard et al., Rheological properties in aqueous media of three new bacterial polysaccarides from marine origin.Food Hydrocolloids. 5(1/2): 167-9 (1991).
Belcher et al., The determination of glucosamine. 79: 201-208 (1953).
Chabut et al., Low molecular weight fucoidan and heparin enhance the basic fibroblast growth factor-induced tube formation of endothelial cells through heparan sulfate-dependent alpha6 overexpression.Mol Pharmacol. 64: 696-702 (2003).
Colliec-Jouault et al., Characterization, chemical modifications and in vitro anticoagulant properties of an exopolysaccharide produced byAlteromonas infernos. Biochem. Biophys. Acta. 1528: 141-51 (2001).
Derwent Publications Ltd., London, GB, Database WPI Section Ch, Class B04, An 1998-501676, XP002368826.
Detillieux et al., Biological activities of fibroblast growth factor-2 in the adult myocardium.Cardiovasc. Res. 57: 8-19 (2003).
Espevik et al., A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes.J. Immunol. Meth. 95: 99-105 (1986).
Filisetti-Cozzi et al., Measurement of uronic acids without interference from neutral sugars.Anal. Biochem. 197: 157-62 (1991).
Giraux et al., Modulation of human endothelial cell proliferation and migration by fucoidan and heparin.Eur. J. Cell. Biol. 77: 352-9 (1998).
Guezennec et al., Deep-sea hydrothermal vents: a new source of innovative bacterial exopolysaccharides of biotechnological interest?.J. Ind. Microb. Biotech. 29: 204-8 (2002).
Guezennec et al., Preliminary chemical characterization of usual eubacterial exopolysaccharides of deep-sear origin.Carbohydr. Polymers. 24: 287-94 (1994).
Guezennec et al., Sulfation and depolymerization of a bacterial exopolysaccaride of hydrothermal origin.Carbohydr. Polym. 37: 19-24 (1998).
Heba et al., The time course of tumor necrosis factor-alpha, inducible nitric oxide synthase and vascular endothelial growth factor expression in an experimental model of chronic myocardial infarction in rats.J. Vasc. Res. 38: 288-300 (2001).
Heilmann et al., Collateral growth: cells arrive at the construction site.Cardiovasc. Surg. 10: 570-8 (2002).
Kamerling et al., Characterization by gas-liquid chromatography-mass spectrometry and proton-magnetic-resonance spectroscopy of pertrimethylsilyl methyl glycosides obtained in the methanolysis of glycoproteins and glycopeptides.Biochem. J. 151: 491-5 (1975).
Luyt et al., Low-molecular-weight fucoidan promotes therapeutic revascularization in a rat model of critical hindlimb ischemia.J. Pharmacol. Exp. Ther. 305: 24-30 (2003).
Marti et al., Angiogenesis in ischemic disease.Thromb. Haemost. 82: 44-52, Suppl. 1, (1999).
Matou et al., Effect of fucoidan on fibroblast growth factor-2-induced angiogenesis in vitro.Thromb Res. 106: 213-21 (2002).
McNeil et al., Growth factors are released by mechanically wounded endothelial cells.J. Cell. Biol. 109: 811-22 (1989).
Montreuil et al., Glycoproteins in: Carbohydrate analysis, a practical approach, IRL Press, Oxford, Chapter 5: 143-204 (1986).
Nishino et al., Anticoagulant and antithrombin activities of oversulfated fucans.Carbohydr. Res. 229: 355-63 (1992).
Raguenes et al., Alteromonas infernus sp. nov., a new polysaccharide-producing bacterium isolated from a deep-sea hydrothermal vent.J. Appl. Microbiol. 82: 422-30 (1997).
Raguenes et al., Description of a new polymer-secreting bacterium from a deep-sea hydrothermal vent,Alteromonas macleodiisubsp.fijiensis, and primary characterization of the polymer.Appl. Environ. Microbiol. 62(1): 67-73 (1996).
Raguenes et al.,Vibrio diaboliucsp. nov., a new polysaccharide-secreting organism isolated from a deep-sea hydrothermal vent polychaete annelid,Alvinella pompejana. Int. J. System. Bacteriol. 47(4): 989-95 (1997).
Rimington, The carbohydrate complex of the serum proteins: Improved method for isolation and re-determination of structure. Isolation of glucosaminodimannose from proteins of ox blood.Biochem. J. 25: 1062-71 (1931).
Rusnati et al., Interaction of angiogenic basic fibroblast growth factor with endothelial cell heparan sulfate proteoglycans. Biological implications in neovascularization.Int. J. Clin. Lab. Res. 26: 15-23 (1996).
Van Dedem et al., Determinations of the molecular mass of low molecular mass (LLM) heparin.Pharmeuropa. 3: 202-18 (1990).
Vivier et al., Signaling function of reconstituted CD16: receptor complex isoform.Int. Immunol. 4(11): 1313-23 (1992).
Weichelman et al., Investigation of the bicinchoninic acid protein assay: Identification of the groups responsible for color formation.Anal. Biochem. 175: 231-7 (1988).
Zubkov et al., Structure of the capsular polysaccharide fromAlteromonassp. CMM 155.Carbohydr. Res. 275: 147-54 (1995).
Combined International Search Report and Written Opinion, PCT/FR2005/001378, Mar. 3, 2006.

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