Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-02-07
2010-02-09
Marschel, Ardin (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S305000, C514S263200
Reexamination Certificate
active
07659278
ABSTRACT:
The present invention provides novel compounds, corresponding to formulae I and II, respectively, which are able to reactivate the apoptosis-inducing function of mutant p53 proteins. This reactivation is provided by restoration of sequence-specific DNA-binding activity and transcriptional transactivation function to mutant p53 proteins, and modulation of the conformation-dependent epitopes of the p53 protein. Accordingly, the substances according to the invention will be used in pharmaceutical compositions and methods for treatment of patients suffering from various types of tumours.
REFERENCES:
patent: 6492386 (2002-12-01), Myers et al.
patent: 00/34276 (2000-06-01), None
patent: 02/24692 (2002-05-01), None
patent: 02/078679 (2002-10-01), None
Chemical Abstract 83:188204 Antitumor chemotherapy. XIV. Cytotoxic activity of molecules possessing an ethylenic double bond substituted in α and β positions by an electron-attracting group. Dore, Jean C.; Viel, Claude (Cent. Etud. Rech. Chim. Org. Appl., Thiais, Fr.). European Journal of Medicinal Chemistry, 10(1), 47-54 (French) 1975.
Bykov Vladimir
Selivanova Galina
Wiman Klas
Aprea AB
Marschel Ardin
Vakili Zohreh
Young & Thompson
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