Use of low levels of mifepristone to treat leiomyomata

Details Use of low levels of mifepristone to treat leiomyomata Use of low levels of mifepristone to treat leiomyomata

1993-05-28

1995-11-21

Jordan, Kimberly R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514967, A61K 3156

Patent

active

054687411

ABSTRACT:
This invention provides for novel unit doses of mifepristone to treat leiomyomata. Compared to unit dosages taught by the prior art, the claimed dosages are low and surprisingly effective. Furthermore, because higher dosages had undesired side effects, the prior art suggested that mifepristone was not suitable for long term clinical uses which are needed to treat leiomyomata. The advantages of this invention include a reduction of surgical morbidity, circumvent the need of a hysterectomy, and cost-effectiveness.

REFERENCES:
patent: 5089488 (1992-02-01), Ottow et al.
Garzo, V. G., et al., "Effects of an Antiprogesterone (RU486) on the Hypothalamic-Hypophyseal-Ovarian-Endometrial Axis During the Luteal Phase of the Menstrual Cycle", Journal of Clinical Endocrinology and Metabolism, vol. 66, No. 3, 508-517 (1988).
Murphy, A. A., et al., "Regression of Uterine Leiomyomata in Response to the Antiprogesterone RU 486", Journal of Clinical Endocrinology and Metabolism. vol. 76, No. 2, 513-517 (1993).

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