Use of lodoxamide to treat ophthalmic allergic conditions

Details Use of lodoxamide to treat ophthalmic allergic conditions Use of lodoxamide to treat ophthalmic allergic conditions

1994-03-21

1995-10-10

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514912, A61K 31275

Patent

active

054571260

ABSTRACT:
Disclosed are methods of using certain defined phenylene dioxamic acids in treating allergic ocular responses, such as, hayfever, conjunctivitis, atopic and keratoconjunctivitis, vernal conjunctivitis, giant capillary conjunctivitis and other diseases where mast cell degranulation are important in the etiology, by topical administration of said active to the affected eye; also disclosed are pharmaceutical compositions comprising said actives.

REFERENCES:
patent: 3993679 (1976-11-01), Hall et al.
patent: 4067995 (1978-01-01), Wright et al.
patent: 4089973 (1978-05-01), Hall et al.
patent: 4169153 (1979-09-01), Wright
patent: 4252813 (1981-02-01), Wright
patent: 4524063 (1985-06-01), Wheeler
Aoki, et al., "Topical Anti-Allergic Activity of Lodoxamide Against a Passive Anaphylaxis Reaction in the Rat Conjunctiva", Investigative Ophthamology and Visual Science, vol. 26, No. 1 (1985).
Watt, et al., "Protective Effect of Lodoxamide Tromethamine on Allergen Inhalation Challenge", Journal of Allergy Clinical Immunology, vol. 66, No. 4, pp. 286-294 (Oct. 1980).
Church, Martin K., "Is inhibition of mast cell mediator release relevant to the clinical activity of anit-allergic drugs?", Agents and Actions, vol. 18, No. 3/4, pp. 288-293 (1986).

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