Use of locally applied DNA fragments

Details Use of locally applied DNA fragments Use of locally applied DNA fragments

1995-06-06

1999-09-21

Stanton, Brian R.

Drug, bio-affecting and body treating compositions

Topical sun or radiation screening, or tanning preparations

514 44, A61K 742, C12N 1500, A01N 4304

Patent

active

059550597

ABSTRACT:
Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or UV-induced dermatoses, and methods for reducing photoaging or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are disclosed. The methods comprise administering to the cells of interest an effective amount of DNA fragments, either single- or double-stranded, or a mixture of both single- and double-stranded fragments, or deoxynucleotides, dinucleotides, or dinucleotide dimers. The DNA fragments, deoxynucleotides, dinucleotides, or dinucleotide dimers can be administered in an appropriate vehicle, such as a liposomal preparation or propylene glycol. Preparations useful in the present methods are additionally disclosed. The preparations comprise DNA fragments, either single- or double-stranded, or a mixture of both single- and double-stranded fragments, or deoxynucleotides, dinucleotides, or dinucleotide dimers, and an appropriate delivery vehicle, such as liposomes or propylene glycol.

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Jayaraman, L. and Prives, C., "Activation of p53 Sequence-Specific DNA Binding by Short Single Strands of DNA Requires the p53 C-Terminus", Cell, 81:1021-1029 (1995).
Orkin et al. Report and recommendations of the panel to assess the NIH investment in research on gene therapy. Distributed by the National Institutes of Health, Dec. 7, 1995.
Chang, G.G. et al. Inhibition of Human Cancer Cell Growth by Periodate-oxidized 3-Aminopyridine Adenine Dinucleotide Diphosphate. Intl. J. of Bio. Chem., (1990) 22 (11) 1259-68, Jan. 31, 1990.

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