Use of liquid fluorocarbons to facilitate pulmonary drug deliver

Details Use of liquid fluorocarbons to facilitate pulmonary drug deliver Use of liquid fluorocarbons to facilitate pulmonary drug deliver

1994-11-04

1996-07-02

Lewis, Aaron J.

Surgery

Respiratory method or device

Means for mixing treating agent with respiratory gas

128913, A61M 1500

Patent

active

055312195

ABSTRACT:
A multiple method step for delivering a medicament to the lungs, in connection with which, a biocompatible perfluorocarbon liquid is introduced into the lungs and the a microparticulate medicament is introduced into the lungs where it is dispersed into the pulmonary spaces which are filled or coated with the perfluorocarbon liquid.

REFERENCES:
patent: 4927623 (1990-05-01), Long, Jr.
patent: 5024995 (1991-06-01), Robertson et al.
patent: 5158536 (1992-10-01), Sekins et al.
patent: 5306483 (1994-04-01), Mautone
Merritt, et al., "Exogenous Surfactant Treatments for Neonatal Respiratory Distress Syndrome and their Potential Role in the Adult Respiratory Distress Syndrome", Drugs 38(4): 591-611 (1989).
Nakayama et al., "Pulmonary dysfunction in surgical conditions of the newborn infant", Crit. Care Med. 19: 926-933 (1991).
Richman, P. et al. "Lung Lavage with Oxygenated Fluorocarbon Improves Gas Exchange and Lung Compliance in Cats with Acute Lung Injury" 1990 World Conference on Lung Health (Boston, MA), Abstract.

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