Use of liposome encapsulated cirprofloxacin as an immunotherapeu

Details Use of liposome encapsulated cirprofloxacin as an immunotherapeu Use of liposome encapsulated cirprofloxacin as an immunotherapeu

1997-04-16

1999-10-19

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424 851, 4242341, 424831, 514312, 514311, 514313, 514314, A61K 91127, A61K 3147, A01N 4342

Patent

active

059685484

ABSTRACT:
Liposome-encapsulated quinolones and specifically liposome-encapsulated ciprofloxacin dramatically enhances macrophage functions, induces NO production and augments the production of cytokines, rendering the composition an immunoprophylactic and immunotherapeutic agent with unique clinical potential. Liposome-encapsulated ciprofloxacin and other quinolones could be extremely useful in antimicrobial, anticancer and AIDS therapies. In such cases, the immunological status of the patient is often compromised or suppressed, making them susceptible to microbial infections and to the development of tumor growth. Selective augmentation of cellular immunity by activation of the microbicidal and tumoricidal activities of macrophages, induction of NO and cytokine production could be of primary importance to such patients in terms of protecting them against microbial infections and inducing their cellular host defense to tumor cells.

REFERENCES:
patent: 4692454 (1987-09-01), Mich et al.
patent: 4923699 (1990-05-01), Kaufman
patent: 5108921 (1992-04-01), Low et al.
patent: 5643599 (1997-07-01), Lee et al.
"Liposome-entrapped Ampicillin in the Treatment of Experimental Murine Listeriosis and Salmonellosis" by E. Fattal et al Antimicrob. Agents Chemother, 35 pp. 770-772, 1991.
Liposome-mediated Treatment of Viral, Bacterial, and Protozoal Infections Popescu et al Liposomes: from Biophysics to therapeutics, In. M. J. Ostro (ed.), Marcel Dekker, Inc. pp. 219-251, 1987.
"Pharmokinetics and in vivo Activity of Liposome Encapsulated Gentamicin" by C. E. Swenson et al Antimicrob. Agents Chemother, 34 pp. 235-240, 1990.
Cells Mater. 3 (3) p. 321 (1993) Abstract only Nicholov.
Antimicrob Agents Chemother. 36 (12) p. 2808 (1992) Abstract only Majumdar.
Zhang et al. "Necessity and sufficiency of beta interferon for nitric oxide production in mouse peritoneal macrophages". infection and Immunity. vol. 62, No. 1, pp. 33-40, Jan. 1994.

Affiliated with

Also associated with

Rating

Use of liposome encapsulated cirprofloxacin as an immunotherapeu does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of liposome encapsulated cirprofloxacin as an immunotherapeu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of liposome encapsulated cirprofloxacin as an immunotherapeu will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2052376