Use of lipid amines formulated with fat or lipid emulsions as va

Details Use of lipid amines formulated with fat or lipid emulsions as va Use of lipid amines formulated with fat or lipid emulsions as va

1981-10-23

1983-07-26

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

424 89, 424 91, 424 92, A61K 3900, A61K 3912

Patent

active

043953948

ABSTRACT:
N,N-higher alkyl-N',N'-bis(2-hydroxyethyl)-propanediamines and N,N-higher alkyl-xylylenediamines formulated with fat or lipid emulsions are useful as vaccine adjuvants of low toxicity. These compositions are useful in conjunction with known immunological substances in order to induce or enhance the immunogenic response. Preferred compositions employ N,N-higher alkyl-N',N'-bis(2-hydroxyethyl)propanediamines, particularly N,N-dioctadecyl-N',N'-bis(2-hydroxyethyl)-propanediamine in Intralipid.

REFERENCES:
patent: 3169094 (1965-02-01), Wretlind
patent: 3872171 (1975-03-01), Cronin et al.
patent: 4034040 (1977-07-01), Cronin et al.
patent: 4069313 (1978-01-01), Woodhour et al.
patent: 4073743 (1978-02-01), Midler et al.
patent: 4173641 (1979-11-01), Kraska
Fortner et al., Am. J. Hosp. Pharm. 32, pp. 582-584 (1975).
Chang and Pearson, Arth. Rheum. 21, pp. 169-170 (1978).

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