Use of ligands which are specific for RXR receptors

Details Use of ligands which are specific for RXR receptors Use of ligands which are specific for RXR receptors

1996-06-19

1999-12-21

Huang, Evelyn Mei

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514443, 514448, 514559, 514560, 514563, 514568, 514569, 514729, A61K 31455, A61K 3138, A61K 3120, A61K 3159

Patent

active

060049871

ABSTRACT:
The present invention relates to the use of at least one ligand which is specific for RXR receptors, in the preparation of a pharmaceutical composition to be administered systemically and intended to increase the cellular proliferation and/or differentiation modulatory activity of a ligand for at least one receptor of the superfamily of steroidal/thyroidal receptors, other than a ligand which is specific for the RXR receptors, and which can heterodimerize with the RXRs, which is applied topically.

REFERENCES:
Mol. Cell. Biol., vol. 15, No. 12, 1995, pp. 6481-6487.
J. Biol. Chem., vol. 267, No. 31, 1992, pp. 22010-22013.
Hashimoto Y et al. Biochem. Biophys. Res. Commun. 166(3), 1300-1307, Feb. 1990.

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