Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1995-04-24
1996-11-12
Hutzell, Paula K.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
435 7021, 4351722, 43524027, 53038823, 53038824, 530300, 514 11, 514 17, A61K 39395, A61K 3812
Patent
active
055737625
ABSTRACT:
A leukemia inhibitory factor antagonist, alone or in combination with an endothelin antagonist, may be used for treatment of heart failure. The antagonist(s) are administered in a chronic fashion, in therapeutically effective amounts, to achieve this purpose.
REFERENCES:
patent: 5270313 (1993-12-01), Burri et al.
patent: 5292740 (1994-03-01), Burri et al.
patent: 5370870 (1994-12-01), Wong et al.
Alphonso et al., "Neutralizing Monoclonal Antibodies to Human Leukemia Inhibitory Factor (LIF)" 1991 Annual Meeting Abstracts p. 49 (1991).
Arai et al., "Cloning and Expression of a cDNA Encoding an Endothelin Receptor" Nature 348(20):730-732 (1990).
Battistini et al., "Growth Regulatory Properties of Endothelins" Peptides 14:385-399 (1993).
Brouty-Boye et al., ".alpha.-Smooth Muscle Actin Expression in Cultured Cardiac Fibroblasts of Newborn Rats" In Vitro Cell. Dev. Biol. 28A:293-296 (Apr. 1992).
Chien, "Molecular Advances in Cardiovascular Biology" Science 260:916-917 (May 14, 1993).
Chien et al., "Regulation of Cardiac Gene Expression During Myocardial Growth and Hypertrophy: Molecular Studies of an Adaptive Physiologic Response" FASEB J. 5:3037-3046 (1991).
Chien et al., "Transcriptional Regulation During Cardiac Growth and Development" Annu. Rev. Physiol. 55:77-95 (1993).
Davis et al., "The Molecular Biology of the CNTF Receptor" Curr. Opin. Cell Biol. 5:281-285 (1993).
Doetschman et al., "The In Vitro Development of Blastocyst-Derived Embryonic Stem Cell Lines: Formation of Visceral Yolk Sac, Blood Islands and Myocardium" J. Embryol. Exp. Morphol. 87:27-45 (1985).
Elias et al., "Cytokine--Cytokine Synergy and Protein Kinase C in the Regulation of Lung Fibroblast Leukemia Inhibitory Factor" American Journal of Physiology 266(10):L426-L435 (1994).
Gough, "Molecular of Leukemia Inhibitory Factor (LIF) and Its Receptor" Growth Factors 7:175-179 (1992).
Hamilton et al., "Induction of Leukemia Inhibitory Factor in Human Synovial Fibroblasts by IL-1 and Tumor Necrosis Factor-.alpha." Journal of Immunology 150(4):1496-1502 (Feb. 15, 1993).
Hilal-Dandan et al., "Coupling of the Type A Endothelin Receptor to Multiple Responses in Adult Rat Cardiac Myocytes" Molecular Pharmacology 45:1183-1190 (1994).
Hilton et al., "Leukemia Inhibitory Factor: A Biological Perspective" J. Cell Biochem. 46:21-26 (1991).
Ihara et al., "Biological Profiles of Highly Potent Novel Endothelin Antagonists Selective for the ET.sub.A Receptor" Life Sciences 50:247-255 (1992).
Ihara et al., "An Endothelin Receptor (ET.sub.A) Antagonist Isolated From Streptomyces Misakiensis" Biochemical and Biophysical Research Communications 178(1):132-137 (Jul. 15, 1991).
Inoue et al., "The Human Endothelin Family: Three Structurally and Pharmacologically Distinct Isopeptides Predicted by Three Separate Genes" Proc. Natl. Acad. Sci. USA 86:2863-2867 (Apr. 1989).
Ito et al., "Endothelin-1 Induces Hypertrophy With Enhanced Expression of Muscle-Specific Genes in Cultured Neonatal Rat Cardiomyocytes" Circulation Research 69(1):209-215 (Jul. 1991).
Iwaki et al., ".alpha.-and .beta.-Adrenergic Stimulation Induces Distinct Patterns of Immediate Early Gene Expression in Neonatal Rat Myocardial Cells" Journal of Biological Chemistry 265(23):13809-13817 (1990).
Jones et al., "Endothelin Stimulates Multiple Responses in Isolated Adult Ventricular Cardiac Myocytes" American Journal of Physiology 263(32):H1447-H1454 (1992).
Katz, "Heart Failure" Physiology of the Heart pp. 638-668 (1992).
Kim et al., "Detection of Human Leukemia Inhibitory Factor by Monoclonal Antibody Based ELISA" Journal of Immunological Methods 156:9-17 (1992).
Kishimoto et al., "Cytokine Signal Transduction" Cell 76:253-262 (1994).
Kishimoto et al., "Interleukin-6 and Its Receptor: A Paradigm for Cytokines" Science 258:593-597 (Oct. 23, 1992).
Kitamura et al., "Multimeric Cytokine Receptors" TEM 5(1):8-14 (1994).
Kurzrock et al., "LIF: Not Just a Leukemia Inhibitory Factor" Endocrine Reviews 12(3):208-217 (1991).
Libby, "Long-Term Culture of Contractile Mammalian Heart Cells in a Defined Serum-Free Medium that Limits Non-Muscle Cell Proliferation" J. Mol. Cell Cardiol. 16:803-811 (1984).
Long et al., "A Growth Factor for Cardiac Myocytes is Produced by Cardiac Nonmyocytes" Cell Reg. 2:1081-1095 (1991).
Lorenzo et al., "Tumor Necrosis Factor .alpha. Stimulates Production of Leukemia Inhibitory Factor in Human Dermal Fibroblast Cultures" Clinical Immunology and Immunopathology 70(3):260-265 (Mar. 1994).
Metcalf, "Leukemia Inhibitory Factor--A Puzzling Polyfunctional Regulator" Growth Factors 7:169-173 (1992).
Miller-Hance et al., "In Vitro Chamber Specification During Embryonic Stem Cell Cardiogenesis" The Journal of Biological Chemistry 268(33):25244-25252 (Nov. 25, 1993).
Nag, "Study of Non-Muscle Cells of the Adult Mammalian Heart: A Fine Structural Analysis and Distribution" Cytobios 28:41-61 (1980).
Pennica et al., "Expression Cloning of Cardiotrophin 1, a Cytokine That Induces Cardiac Myocyte Hypertrophy" Proceedings of the National Academy of Sciences, USA 92:1142-1146 (Feb. 1995).
Robbins et al., "Mouse Embryonic Stem Cells Express the Cardiac Myosin Heavy Chain Genes During Development in Vitro" Journal of Biological Chemistry 265(20):11905-11909 (1990).
Shubeita et al., "Endothelin Induction of Inositol Phospholipid Hydrolysis, Sarcomere Assembly, and Cardiac Gene Expression in Ventricular Mytocytes" Journal of Biological Chemistry 265(33):20555-20562 (1990).
Simpson et al., "Differentiation of Rat Mytocytes in Single Cell Cultures with and without Proliferating Nomyocardial Cells" Circ. Res. 50(1):101-116 (1982).
Simpson et al., "Myocyte Hypertrophy in Neonatal Rat Heart Cultures and Its Regulation by Serum and by Catechcolamines" Circ. Res. 51(6):787-801 (1982).
Suzuki et al., "Endothelin-1 Stimulates Hypertrophy and Contractility of Neonatal Rat Cardiac Myocytes in a Serum-Free Medium. II" Journal of Cardiovascular Pharmacology 17(7):S182-S186 (1991).
Webb et al., "The Endothelin Receptor Antagonist, BQ-123, Inhibits Angiotensin II-induced Contractions in Rabbit Aorta" Biomedical and Biophysical Research Communications 185(3):887-892 (Jun. 30, 1992).
Wei et al., "Endothelin in Human Congestive Heart Failure" Circulation 89(4):1580-1586 (Apr. 1994).
Yamamori et al., "The Cholinergic Neuronal Differentiation Factor from Heart Cells is Identical to Leukemia Inhibitory Factor" Science 246:1412-1416 (1989).
Yanagisawa and Masaki, "Molecular Biology and Biochemistry of the Endothelins" TIPS 10:374-378 (Sep. 1989).
Harris et al, TIBTECH 11:42-44, 1993.
Pepper et al, J. Cell. Sci. 108:78-83, 1995.
Metcalf and Gearing, PNAS USA 86:5948-5952, 1989.
Shen and Heder, PNAS USA 89:8240-8244, 1992.
Ferrara Napoleone
King Kathleen
Luis Elizabeth
Mather Jennie P.
Paoni Nicholas F.
Genentech Inc.
Hasak Janet E.
Hutzell Paula K.
Johnson Nancy A.
Torchia, Ph.D Timothy E.
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