Use of leflunomide for inhibiting interleukin 8

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 3142

Patent

active

055479715

ABSTRACT:
The use of leflunomide for inhibiting interleukin 8 N-(4-Trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide is an effective compound for preventing and treating disorders in which interleukin 8 is involved. It is used as a pharmaceutical.

REFERENCES:
patent: 4351841 (1982-09-01), Kammerer et al.
patent: 4965276 (1990-10-01), Bartlett et al.
Peveri et al., "A Novel Neutrophil-Activating Factor Produced By Human Mononuclear Phagocytes", J. Exp. Med., 167:1547-1559 (1988).
Djeu et al, "Functional Activation of Human Neutrophils By Recombinant Monocyte-Derived Neutrophil Chemotactic Factor/IL-8", J. Immunol., 144(6):2205-2210 (1990).
Bartlett et al., "Leflunomide (HWA 486), A Novel Immunomodulating Compound For The Treatment Of Autoimmune Disorders And Reactions Leading To Transplantation Rejection", Agents and Actions, 32:10-21 (1991).
Furuta et al., "Production and Characterization of Recombinant Human Neutrophil Chemotactic Factor", J. Biochem., 106:436-441 1989.
Van Damme et al., "A Novel NH.sub.2 -Terminal Sequence-Characterized Human Monokine Possessing Neutrophil Chemotactic, Skin-Reactive, And Granulocytosis-Promoting Activity", J. Exp. Med., 167:1364-1376 (1988).
Elford et al., "Induction Of Neutrophil-Mediated Cartilage Degradation By Interleukin-8", Arthritis and Rheumatism, 34(3): 325-332 (1991).
Farina et al., "Monocyte-Derived Neutrophil Chemotactic Factor (MDNCF): A Stimulator Of Neutrophil Function", Faseb J., 3:1333 (1989).
Larsen et al., "The Neutrophil-Activating Protein (NAP-1) Is Also Chematic For T Lymphocytes", Science, 243:1464-1466 (1989).
Axton et al., "Novel Immunosuppressive Butenamides", J. Chem. Soc. Perkin Trans. 1:2203-2213 (1992).
Yoshimura et al., "Neutrophil Chemotactic Factor Produced By Lipopolysaccharide (LPS)-Stimulated Human Blood Mononuclear Leukocytes: Partial Characterization and Separation From Interleukin 1 (IL 1)", J. Immunol., 139(3):788-793 (1987).
Schroder et al., "Purification and Partial Biochemical Charactrization Of A Human Monocyte-Derived, Neutrophil-Activating Peptide That Lacks Interleukin 1 Activity", J. Immmunol., 139(10):3474-3483 (1987).
T. T. Glant et al., "Immunomodulation of Proteoglycan-Induced . . .", Immunopharmacology, 23:105-116 (1992).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of leflunomide for inhibiting interleukin 8 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of leflunomide for inhibiting interleukin 8, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of leflunomide for inhibiting interleukin 8 will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2331008

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.