Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Patent
1996-11-07
1999-11-09
Eisenschenk, Frank C.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
424418, 536114, 536123, 53612312, A61K 700, A61K 748, C07G 1700, C07H 108
Patent
active
059809167
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
The present invention relates essentially to the use of laminarin and oligosaccharides derived from laminarin in cosmetology and for the manufacture of a medicine destined for the treatment of the skin.
It is known that laminarin is a storage polymer of brown algae and consists of polysaccharides whose structures differ slightly according to the nature of the alga.
In general terms, laminarin possesses a molecular mass of less than about 30000 Daltons and consists of 20 to 60 D-glucopyranoside units distributed in a main linear chain, in which these units are joined by .beta.(1-3) linkages, and branches joined to this main chain by .beta.(1-6) linkages.
Some of these chains have a reducing terminal unit consisting of a mannitol unit. The existence of mannose units within this structure is also noted.
Laminarin is generally extracted from brown macrophytt marine algae of the Pheophyceae type, and in particular the Fucales or the Laminariales.
Various extraction methods can be used to obtain the laminarin.
Reference may be made for example to the method described by Black et al., Appl. Chem., 1951, 1, pages 505 to 517.
More generally, laminarin can be obtained from brown algae by any extraction process which enables the constituents other than laminarin (wall polysaccharides, salts, etc.) to be successively removed.
In particular, these processes use steps involving grinding, precipitation in an acid or basic medium, ultrafiltration and dialysis.
Laminarin is also marketed, for example by Sigma Chimie SARL.
Various scientific publications describe the eliciting properties of laminarin, suggesting its use for enhancing plant defense reactions.
Thus Netzer et al. reveal that an infection with the pathogen S. oxysporum triggers the induction of laminarinase (Biological abstracts, vol. 68, No. 1, 1979).
Likewise, Bonhoff et al. reveal the properties of laminarin as an elicitor of phytoalexin and callose (Biological abstracts, vol. 86, No. 4, 1988).
Furthermore, Kurosaki et al. (Biological abstracts, vol. 35, No. 2, 1988) and Pearce (Biological abstracts Vol. 74, No. 8, 1982) confirm the eliciting effects of laminarin, in particular in respect of lignification, while at the same time state that these effects are weak compared with those of the known elicitors.
The French Patent Application No. 92 08387 of the Applicants confirm the eliciting properties of laminarin and its use for enhancing plant defense reactions, and further reveal that laminarin has the properties of an .alpha.-amylase elicitor causing an accelerating action on seed germination and plant growth.
Furthermore, it is known that sulfated laminarin has interesting pharmaceutical properties, in particular anti-coagulant and hypoi-holesterinemiant properties. (K. C. Guven et al., Introduction to Applied Physiology, 1990, pages 67 to 92).
SUMMARY OF THE INVENTION
It was discovered, and this constitutes the basis of the present invention, that laminarin, the oligosaccharides derived from laminarin and the compositions containing them, possess stimulant, regenerating, revitalizing, and energizing effects on the fibroblasts of the human dermis, support tissue of the skin and on the keratinocytes of the human cutaneous epidermis, as well as on target cells of cosmetic or pharmaceutical products, notably dermatological products.
These effects have been demonstrated by the study of the stimulation of the neosynthesis of proteins in cultures of skin cells.
The cell cultures in fact allow the measurement of the Tolerance and the activity of products under test, insofar as where, in appropriate culture conditions, these cells retain functions close to those expressed in vivo.
It seems, without this constituting a theoretical interpretation, that the effects of stimulation obtained are due to the two following mechanisms: and the compositions containing them, would have a nutritious effect and would provide cells with elements absent or present in an insufficient quantity in the culture medium; a hormone (<<hormone-like >
REFERENCES:
patent: 5508033 (1996-04-01), Briand
Di-Luzio et al. Journal of the Reticuloendothelial Society 8(5): 465-473, 1970.
Fedorov et al. (A) Chemical Abstracts 116(4) p. 444 Abstract No. 27871, 1992.
Fedorov et al. (B) Chemical Abstracts 116(4) p. 444 Abstract No. 27820, 1992.
Fedorov et al. (C) Chemical Abstracts 116(1) p. 490 Abstract No. 91169, 1992.
Hud'Homme Fabienne
Levasseur Florence
Yvin Jean-Claude
Eisenschenk Frank C.
Laboratories Goemar S.A.
Zeman Mary K
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