Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Reexamination Certificate
2008-05-06
2008-05-06
Ewoldt, G. R. (Department: 1644)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
C435S355000
Reexamination Certificate
active
10503402
ABSTRACT:
The present invention relates to the use of L-α-lysophosphatidylcholine and/or an equivalent compound for the differentiation of monocytes into mature denditric cell.The present invention also relates to a method for differentiation monocytes into mature denditric cells according to which monocytes are provided in a medium suitable for their differentiation and L-α-lysophosphatidylcholine and/or an equivalent compound is added to said medium.
REFERENCES:
patent: 4746652 (1988-05-01), Buckalew, Jr. et al.
patent: 5434182 (1995-07-01), Isaacs et al.
patent: 2004/0219672 (2004-11-01), Lotteau et al.
patent: WO 98/57631 (1998-12-01), None
patent: WO 03/006634 (2003-01-01), None
Perrin-Cocon et al, 2001, Oxidized LDL promotes mature dendritic cell transition from differentiating monocyte. J. Immunol. vol. 167: 3785-91.
Frostegard et al., 1997, Platelet activating factor and oxidized LDL induce immune activation by a common mechanims. Arter. Thromb., Vasc. Biol. vol. 17: 963-968.
Labeur et al., 1999, Generation of tumor immunity by BM-DC correlates with dendritic cell maturation stage, J. Immunol., vol. 162: 168-175.
Vuong et al. , 1999, Hypoalbuminemia incrases lysophsphatidylcholine in LDL of normocholesterolemic subjects. Kidney international, vol. 55: 1005-1010.
Sigma Product information for L-a-lysophosphatidylcholine. 1998.
Jeras et al., 2005, Transplant Immunology vol. 14: 231-244.
Lyakh et al., 2005, J. Immunol. vol. 174: 2061-2070.
Weber, Christian et al. “Enhancement of Monocyte Adhesion to Endotherial Cells by Oxidatively Modified Low-Density Lipoprotein is Mediated by Activation of CD11b”Biochem. and Biophy. Rsrch Coms. pp. 621-628 Jan. 17, 1995.
Dichmann, Stefan et al. “Downregulation of Platelet-Activing Factor Responsiveness During Maturation of Human Dendritic Cells.”Journal of Cellular Physiologypp. 394-400 Jul. 10, 2000.
Kabarowski, Janusz H.S et al. “Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A.”Sciencepp. 702-705 Jul. 27, 2001.
Carson, Monica J. et al. “The Push-Me Pull-You of T Cell Activation.”Sciencepp. 618-619 Jul. 27, 2001.
Wanten. G. J. A. et al. “Influence of Structurally Different Lipid Emulsions on Human Neutrophil Oxygen Radical Production.”European Journal of Clinical Investigationpp. 357-363 1999.
Beales, Philip E. et al. “Troglitazone Prevents Insulin Dependent Diabetes in the Non-Obese Diabetic Mouse.”European Journal of Pharmacologypp. 221-225 1998.
Niino, Masaaki et a. “Amerliorization of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice by an Agonist of Peroxisome Proliferator-Activated Receptor-Y.”Journal of Neuroimmunologypp. 40-48 2001.
S. Sozzani et al., “Human monocyte-derived and CD34+ cell-derived dendritic cells express functional receptors for platelet activating factor,”FEBS Letters, vol. 418, No. 1-2, pp. 98-100, Nov. 1997.
F. Coutant et al., “Mature dendritic cell generation promoted by lysophosphatidylcholine,”Journal of Immunology, vol. 169, No. 4, pp. 1688-1695, Aug. 2002.
D. Granato et al., “Effects of parenteral lipid emulsions with different fatty acid composition on immune cell functions in vitro,”Journal of Parental and Enteral Nutrition, vol. 24, No. 2, pp. 113-118, Mar. 2000.
Andre Patrice
Lotteau Vincent
Biomerieux
Ewoldt G. R.
Institut National de la Sante et de la Recherche Medicale
Juedes Amy
Oliff & Berridg,e PLC
LandOfFree
Use of L-α-lysophosphatidylcholine to obtain the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of L-α-lysophosphatidylcholine to obtain the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of L-α-lysophosphatidylcholine to obtain the... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3953205