Use of L-deprenyl for retention of specific physiological functi

Details Use of L-deprenyl for retention of specific physiological functi Use of L-deprenyl for retention of specific physiological functi

1990-08-31

1992-09-29

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514879, 514649, 514646, A61K 31135

Patent

active

051514494

ABSTRACT:
L-Deprenyl and pharmaceutically acceptable analog forms thereof are used at specific dosage levels and frequency of dosage to slow the normal age dependent deterioration of renal function, to provide increased exploratory behavior level of activity at any given age and in order to retard age deterioration of cognitive abilities, especially spatial learning ability. The treatment can be especially useful for mammals, for examples pets such as dogs and cats.

REFERENCES:
patent: 4564706 (1986-01-01), Ecsery et al.
patent: 4871550 (1989-10-01), Millman
Knoll, "The Pharmacology of Selective Mao Inhibitors", Monoamine Oxidase Inhibitors--The State of the Art, 1981, pp. 45-61.
Knoll, et al., "Long-Lasting, True Aphrodisiac Effect of (-)-Deprenyl in Sexually Sluggish Old Male Rats," Modl Probl. Pharmacopsychiat., vol. 19 pp. 135-153 (1983).
Milgram, et al., "Maintenance on L--Deprenyl Prolongs Life in Aged Male Rats", Life Sciences, vol. 47, 190, pp. 415-420.
Knoll, "Extension of Life Span of Rats by Long-Term (-)Deprenyl Treatment", The Mount Sinai Journal of Medicine, vol. 55, No. 1, Jan. 1988, pp. 67-74.
Knoll, "The Striatal Dopamine Dependency of Life Span in Male Rats, Longevity Study with (-)Deprenyl", Mechanisms of Ageing and Developments, 46, (1988) 237-262.

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