Use of L-carnitine in the treatment of toxic effects induced by

Details Use of L-carnitine in the treatment of toxic effects induced by Use of L-carnitine in the treatment of toxic effects induced by

1987-07-02

1988-10-25

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

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Taste or smell or chemical irritation to the eye, nose, or...

514547, A61K 31225

Patent

active

047803088

ABSTRACT:
Oral or parenteral administration of 10 to 30 mg/kg/day of L-carnitine (or an equivalent amount of a pharmacologically acceptable salt thereof) both during preanesthesia and post-operative phase antagonizes the toxic effects (particularly on kidneys and liver) induced by inhalation of halogen-containing general anesthetics such as, typically, halotane.

REFERENCES:
Toninello et al. "L-carnitine effect on Halothane-Treated Mitochondria," Biochem. Pharmacol., 35(22), pp. 3961-3964, 1986.
Branca et al., "Involvement of Long-chain Acyl CoA in the Antagonist Effects of Halothane and L-carnitine on Mitochondrial Energy Linked Processes," Biochem. Biophys. Res. Commun., 139(1), 303-307, 1986.

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