Use of L-carnitine and its alkanoyl derivatives for reducing the

Details Use of L-carnitine and its alkanoyl derivatives for reducing the Use of L-carnitine and its alkanoyl derivatives for reducing the

1997-09-08

1999-09-28

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 19, 514551, A61K 3144, A61K 3800, A61K 3122

Patent

active

059589418

ABSTRACT:
The use of L-carnitine or of an alkanoyl L-carnitine or their pharmacologically acceptable salts is described for producing a medicament for inhibiting nephrotoxicity and vasculotoxicity resulting from the administration of an immunosuppressant drug such as cyclosporin-A, tacrolimus, rapamicine and deoxyspergualine.

REFERENCES:
Ochiai et al, Transplantation, vol. 48, 189-193, (1989).
Fung et al, Transplantation, Proceedings, vol. 23, No. 3, 1902-1905, (1991).
Anzai et al., J of Antibiotics, Ser A, vol. XV, No. 2, 110-111, (1962).
Kino et al, J of Antibiotics, vol. XL, No. 9, 1249-1255, (1987).
Dreyfuss et al, European J. Appl. Microbiol 3, 125-133, (1976).
Takeuchi et al, J of Antibiotics, vol. XXIV, No. 12, 1619-1621 (1981).

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