Drug – bio-affecting and body treating compositions – Dentifrices
Patent
1995-07-18
1998-07-28
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
424 54, A61K 716, A61K 722
Patent
active
057859515
ABSTRACT:
The present invention relates to methods and compositions for prevention or treatment of bone loss due to periodontal disease, oral osseous surgery, periodontal flap surgery, tooth extraction, dental implants, or scaling and root planing comprising topical administration, to mucosal tissues of the oral cavity, of a composition having from about 0.001% to about 0.2% ketorolac in the oral cavity.
REFERENCES:
patent: 4089969 (1978-05-01), Muchowski et al.
patent: 4578390 (1986-03-01), Jensen et al.
patent: 4780320 (1988-10-01), Baker
patent: 4873340 (1989-10-01), Muchowski et al.
patent: 4874871 (1989-10-01), Fleming et al.
patent: 4919939 (1990-04-01), Baker
patent: 4933172 (1990-06-01), Clark et al.
patent: 4965262 (1990-10-01), Kametaka et al.
Barshun, C.L., L.S. Olanoff, D.D. Gleason, E.L. Adkins & N.F.H. Ho, "Human Buccal Absorption of Flurbiprofen," Clin. Pharmacol. Ther., vol. 44, No. 2, pp. 225-231 (Aug. 1988).
Caldwell, J., A.J. Hutt & S. Fournel-Gigleux, "The Metabolic Chiral Inversion and Dispositional Enactioselectivity of the 2-Arylpropionic Acids and their Biological Consequences", Biochemical Pharmacology, Vo., 37, No. 1,(1988), pp. 105-114.
Chin, R.C. & Y. Chen, Orthopaedic Research Society Meeting materials from 35th Annual Meeting, p. 119.(Feb. 6-8, 1989).
Elattar, T. M. A., H. S. Lin and D. E. Tira, "The Effect of Non-steroidal Anti-inflammatory Drugs on the Metabolism of .sup.14 C-Arachidonic Acid by Human Gingival Tissue," J. Dent. Res., vol. 62, No. 9, pp.975-979(Sep. 1983).
Feldman, R.S., B. Szeto, H.H. Chauncey & P. Goldhaber, "Non-Steroidal Anti-inflammatory Drugs in the Reduction of Human Aveolar Bone Loss", Journal of Clinical Periodontology, vol. 10, No. 2 pp. 131-136(1983).
Gaffar, A., J. Afflitto, E.J. Coleman, L. Steinberg & D. Fine, "Efficacy of Ibuprofen Rinse in a Subgingival Irrigator on Periodontitis in Primates", Journal of Dental Research, vol. 68 (Spec. Issue), p.970, Abstract No. 830(Mar. 1989).
Gonzalez-Younes, I., J. G. Wagner, D. A. Gaines, J. J. Ferry & J. M. Hageman, "Absorption of Flurbiprofen Through Buccal Mucosa," Journal of Pharmaceutical Sciences, vol., 80, No. 9, pp. 820-823(Sep. 1991).
Heasman, P. A., R.A. Seymour & P.F. Boston, "The Effect of a Topical Non-Steroidal Anti-Inflammatory Drug on the Development of Experimental Gingivitis in Man", Journal of Clinical Periodontology, vol. 16, pp. 353-358(Jul. 1989).
Heasman, P.A., A. Ward, A.W. Barrett, R.A. Seymour & G. Edwards, "Flurbiprofen in Human Crevicular Fluid Analyzed by High-Performance Liquid Chromatography," J. Periodont. Res., vol. 25, pp. 88-92(1990).
Hutt, A.J. & J. Caldwell, "The Metabolic Chiral Inversion of 2-Arylpropionic Acids --A Novel Route with Pharmacological Consequences", Journal of Pharmacy and Pharmacology, vol. 35(1983), pp. 693-704.
Jeffcoat, M. K., R. Page, M. Reddy, R. Cogen, P. Waite, K. Palcanis, R.C. Williams & C. Basch, "Naproxen as an Adjunct in the Treatment of Rapidly Progressive Periodontitis", Journal of Dental Research, vol. 68, Special Issue(Mar. 1989), Abstract No. 1055, p. 999.
Jeffcoat, M.K., R.C. Williams, M.S. Reddy, R. English & P. Goldhaber, "Flurbiprofen Treatment of Human Periodontitis: Effect on Alveolar Bone Height and Metabolism", Journal of Periodontal Research, vol. 23(1988), pp. 381-385.
Jeffcoat, M.K., R.C. Williams, W.J. Wechter, H.G. Johnson, M.L.. Kaplan, J.S. Gandrup & P. Goldhaber, "Flurbiprofen Treatment of Periodontal Disease in Beagles," Journal of Periodontal Research, vol. 21, pp. 624-633(1986).
Johnson, R.H., G.C. Armitage, C. Francisco & R.C. Page, "Assessment of the Efficacy of Nonsteroidal Anti-inflammatory Drug. Naprosyn.RTM., in the Treatment of Gingivitis", J. Periodont.. Res., vol. 25, pp. 230-235(1990).
Lasfargues, J.J & J.L. Saffar,"Effect of Indomethacin on Bone Destruction During Experimental Periodontal Disease in the Hamster," Journal of Periodontal Research, vol. 18, pp. 110-117(1983).
Mroszcsak, E.J., F.W. Lee, D. Combs, F.H. Sarnquist, B-L Huang, A.T. Wu, L.G. Tokes, M.L. Maddox & D.K. Cho, "Keterolac Tromethamine Absorption, Distribution, Metabolism, Excretion, and Pharmacokinetics in Animals and Humans", Drug Metabolism & Disposition, vol. 15, No. 5, (1987), p. 618-626.
Nichols, F.C., D.A. Weber, R.L. Baker. B.R. Rifkin & A. Durakovic, "Bone Imaging of Experimentally Induced Periodontal Disease: Effects of Indomethacin," J. Dent. Res. vol. 58, Spec. Issue A, p. 415, Abstract No. 1298,(Jan. 1979).
Nuki, K., W.A. Soskolne, L.G. Raisz, K. S. Kornman & C. Alander, "Bone Resorbing Activity of Gingiva from Beagle Dogs Following Metronidazole and Indomethacin Therapy," Jornal of Periodontal Research, vol. 16. No. 2, pp. 205-212(Mar. 1981).
Nyman, S., H.E. Schroder & J. Lindhe, "Suppression of Inflammation and Bone Resorption by Indomethacin During Experimental Periodontitis in Dogs," J. Periodont., vol. 50, No. 9, pp. 450-461(Sep. 1979).
Offenbacher, S., L. D. Braswell, A.S. Loos, H.G. Johnson, C.M. Hall, H. McClure, J.L. Orkin, E.A. Strobert, M.D. Green & B.M. Odle, "The Effects of Flurbiprofen on the Progression of Periodontitis in Macca Mulatta," Journal of Periodontal Research, vol. 22, pp. 473-481 (1987).
Offenbacher, S., R.C. Williams, M. Jeffcoat, H. Howell, C.S. Mayambala, C.M. Hall & H.G. Johnson, "NSAIDs Effect on Periodontitis Sugests Central Role of PGEs and Thromboxane A.sub.2," Journal of Dental Research, vol. 68, Spec. Issue, p. 240, Abstract #474, (Mar. 1989).
Reiff, R.L., C.L. White, D.N. Deines and T. Elattar, "Buffered Aspirin Oral Rinse in Reduction of Gingival Inflammation," J. Dent. Res., vol. 65, Spec. Issue, p. 788, Abstract#562 (Jun. 1986).
Rieger, M.M., "Topical Anti-inflammatory Therapy Against Periodontal Disease: A Historical Survey,"Clinical Preventive Dentistry, vol. 9, No. 4, pp. 18-22 (1987).
Rooks, W.H., P.J. Mahoney, L.D. Schott, M.E. Schuler, H. Sevelius, A.M. Strosberg, L. Tanenbaum, A.J. Tomolonis, M.B. Wallach, D. Waterbury & J.P. Yee,"The Analgesic and Anti-inflammatory Profile of Ketorolac and its Tromethamine Salt", Drugs Experimental Clinical Research, vol. XI, No. 8(1985), pp. 479-492.
Stalker, D.J. & S.R. Pollock, "Bioavailability of Flurbiprofen following Buccal Administration," Pharmaceutical Research, vol.8, No. 5, pp. 605-607, (1991).
"Vascular Endothelium Receptors and Transduction Mechanisms," NATO Series A: Life Sciences, vol. 175, p. 107(J.D. Catravas, C.N. Gillis & U.S. Ryan, Eds., Jul. 1989).
Vogel, R.I., "The Experimental Use of Anti-Inflammatory Drugs in the Treatment of Periodontal Diseases", Journal of Periodontology, vol. 56(suppl.)(1985), pp. 88-92.
Vogel, R.I., L.Schneider & D. Goteiner, "The Effects of a Topically-Active Non-Steroidal Anti-Inflammatory Drug on Ligature-Induced Periodontal Disease in the Squirrel Monkey", Journal of Clinical Periodontology, vol. 13(1986), pp. 139-114.
Vogel, R.I., S. A. Cooper, L.G. Schneider & D. Goteiner, "The Effects of Topical Steroidal and Systemic Nonsteroidal Anti-Inflammatory Drugs on Experimental Gingivitis in Man", Journal of Periodontology, vol. 55, No. 4 91984), pp. 247-251.
Waite, I.M., C.A. Saxton, A. Young, B. J. Wagg & M. Corbett, "The Periodontal Status of Subjects Receiving Non-Steroidal Anti-Inflammatory Drugs," Journal of Periodontal Research, vol. 16, No. 1 (Jan. 1981), p. 100-108.
Williams, R.C., "Non-Steroidal Anti-Inflammatory Drugs in Periodontal Disease," Non-Steroidal Anti-Inflamatory Drugs, A.J. Lewis, D.E. Furst, eds., Marcel Dekker, pub., (1987), pp. 143-55.
Williams, R., M.Jeffcoat, H. Howell, M. Reddy. C.Hall, H. Johnson & P. Goldhaber, "Naproxen Treatment of Periodontitis in Beagles", Journal of Dental Research, p. 243, Abstract No. 491, (Mar. 1989).
Williams, R.C., M.K. Jeffcoat, T.H. Howell, M. Reddy, C. M. Hall, H.G. Johnson, W.J. Wechter. & P/. Goldhaber, "Indomethacin or Flurbiprofen Treatment of Periodontitis in Beagles: Comparison of Effect on Bone Loss", Journal of Periodontal Research, vol.22(1987), pp. 403-407.
Williams, R.C., M.K. Jeffcoat, T.H. Howell, M.S. Reddy, H.G. Johnson, C.M. Hall & P. Goldhaber, "Topical Flurbiprofen Treatment of Periodontitis in Beagles"
Buchanan William
Doyle Matthew Joseph
Kelm Gary Robert
Pickrum Harvey Marvin
Graff IV Milton B.
Mohl Douglas C.
Rasser Jacobus C.
Rose Shep K.
The Procter & Gamble & Company
LandOfFree
Use of ketorolac for treatment of oral diseases and conditions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of ketorolac for treatment of oral diseases and conditions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of ketorolac for treatment of oral diseases and conditions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-20810