Use of isolated domains of type IV collagen to modify cell and t

Details Use of isolated domains of type IV collagen to modify cell and t Use of isolated domains of type IV collagen to modify cell and t

1994-06-30

1996-10-22

Sayala, Chhaya D.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

530356, C12N 500, C07K 100

Patent

active

055676090

ABSTRACT:
The instant invention demonstrates that the 7S and NC1 domains of type IV collagen disrupts cell aggregation and tissue development. Structural changes in mesoglea, inhibition of cell proliferation, and changes in cell differentiation patterns accompanies the blockage of cell aggregates which indicate that blockage may be due to alterations in mesoglea (extracellular matrix) structure with accompanying effects on cell behavior. Type IV collagen has a critical role in the initial formation of mesoglea and that perturbation of mesoglea formation affects cell division, cell differentiation, and morphogenesis.

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