Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1995-06-30
1997-11-25
Lankford, Blaine
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4352402, 530356, 514 2, 514 21, 514801, C12N 500, A61K 3800
Patent
active
056911823
ABSTRACT:
The instant invention demonstrates that the 7S domain of type IV collagen disrupts cell aggregation and tissue development. Structural changes in mesoglea, inhibition of cell proliferation, and changes in cell differentiation patterns accompanies the blockage of cell aggregates which indicate that blockage may be due to alterations in mesoglea (extracellular matrix) structure with accompanying effects on cell behavior. Type IV collagen has a critical role in the initial formation of mesoglea and that perturbation of mesoglea formation affects cell division, cell differentiation, and morphogenesis.
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Hudson Billy G.
Sarras, Jr. Michael P.
Lankford Blaine
University of Kansas Medical Center
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