Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2004-02-02
2010-06-29
Long, Scott (Department: 1633)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S366000, C435S007200
Reexamination Certificate
active
07745113
ABSTRACT:
The present invention provides in vitro methods of expansion and propagation of undifferentiated progenitor cells and more specifically undifferentiated progenitor cells containing Islet1, a marker apparently unique to proliferating cardiac stem cells. Methods are described for isolation of stem cell populations as well as for provoking expansion and propagation of undifferentiated progenitor cells without differentiation, to provide cardiac repair or improve cardiac function, for example.
REFERENCES:
patent: WO 02/12498 (2002-02-01), None
Amit et al (Developmental Biology. 2000.227: 271-278).
Ericson (Science. Jun. 12, 1992; col. 256: 1555-1560).
Hamburger et al. (J. Morphol. 1951; 88: 49-92).
Encyclopaedia Brittanica—somite definition.
Edinburgh Mouse Atlas.
ISSCR—Glossary of Stem Cell Related Terms.
Boyer et al. (Cell. 2005; 122: 947-956).
Boheler et al. (Circulation Research. 2002; 91: 189-201).
Pfaff et al. (Cell 1996; 84:309-320).
Schilling et al. (Developmental Biology 1999. 210: 277-287).
Yuan et al. (The Anatomical Record. 2000; 260:204-207).
Ahlgren et al., “Independent Requirement for ISL1 in Formation of Pancreatic Mesenchyme and Islet Cells.”Nature385(6613):257-260 (1997).
Cai et al., “IsI1 Identifies a Cardiac Progenitor Population that Proliferates Prior to Differentiation and Contributes a Majority of Cells to the Hart.”Developmental Cell5:877-889 (2003).
Pfaff et al., “Requirement for LIM Homeobox GeneIsI1in Motor Neuron Generation Reveals a Motor Neuron-Dependent Step in Interneuron Differentiation.”Cell84:309-320 (1996).
Stenman et al., “Identification of Two Distinct Progenitor Populations in the Lateral Ganglionic Eminence: Implications for Striatal and Olfactory Bulb Neurogenesis.”The Journal of Neuroscience23(1):167-174 (2003).
Cai Chenleng
Chen Ju
Chien Kenneth R.
Evans Sylvia M.
Laugwitz Karl-Ludwig
DLA Piper (LLP) US
Long Scott
The Regents of the University of California
LandOfFree
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