Use of ionic cloud point modifiers to prevent particle aggregati

Details Use of ionic cloud point modifiers to prevent particle aggregati Use of ionic cloud point modifiers to prevent particle aggregati

1992-12-04

1994-03-29

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424499, 424495, 424487, A61K 914

Patent

active

052982629

ABSTRACT:
This invention discloses a composition comprised of nanoparticles having a surface modifier adsorbed on the surface thereof and an anionic or cationic surfactant as a cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier. A preferred surface modifier is tyloxapol. Preferred anionic surfactants are dioctylsulfonesuccinate, sodium dodecyl sulfate and sodium oleate. Preferred cationic surfactants are dodecyltrimethylammonium bromide and cetrimide tetradecyl ammonium bromide. This invention further discloses a method of making nanoparticles having a surface modifier adsorbed on the surface and an anionic or cationic surfactant as a cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.

REFERENCES:
patent: 3272700 (1966-09-01), Sluppe
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4540602 (1985-09-01), Motoyama et al.
patent: 4826689 (1989-05-01), Violanto et al.
patent: 4826821 (1989-05-01), Clements
patent: 5055288 (1991-10-01), Lewis et al.
patent: 5133908 (1992-07-01), Stainmesse et al.
patent: 5145684 (1992-09-01), Liversidge et al.
"Hydrophile-Lipophile Balance and Cloud Points of Nonionic Surfactants"; J. Pharm Sci., vol. 58, No. 12, Dec. 1969, pp. 1443-1449.

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