Use of intratracheal administration of SOD to protect humans fro

Details Use of intratracheal administration of SOD to protect humans fro Use of intratracheal administration of SOD to protect humans fro

1991-04-29

1992-05-26

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Oxidoreductases

424 941, A61K 3750

Patent

active

051166160

ABSTRACT:
The subject invention provides a method of protecting a human from lung injury due to hyperoxia and hyperventilation which comprises intratracheally administering to the human an amount of free CuZnSOD effective to protect the human from lung injury due to hyperoxia and hyperventilation.

REFERENCES:
A. M. Gonenne et al., JAP 67:1007-1042 (1989).
Crapo et al., Structural and Biochemical Changes in Rat Lungs Ocurring During Exposures to Lethal and Adaptive Doses of Oxygen, American Review of Respiratory Disease, 122:123-143 (1980).
Walthar et al., Prevention of Oxygen Toxicity with Superoxide Dismutase and Catalase in Premature Lambs, Journal of Free Radicals in Biology & Medicine 2:289-293 (1986).
Padmanabhan et al., Protection Against Pulmonary Oxygen Toxicity in Rats by the Intratracheal Administration of Liposome-Encapsulated Superoxide Dismutase or Catalase, Am. Rev. Respir. Dis 132:164-167 (1985).
Turrens et al., Protection Against Oxygen Toxicity by Intravenous Injection of Liposome-Entrapped Catalase and Superoxide Dismutose, J. Clin. Invest. 73:87-95 (1984).
Crapo et al., The Failure of Aerosolized Superoxide Dismutose to Modify Pulmonary Oxygen Toxicity American Review of Respiratory Disease 115:1027-1033.
Seo et al., The Effect of Intratracheally Administered Free and Liposome Entrapped Superoxide Dismutose and Catalase on Experimentally Exposed Hyperoxic Injury in Rats' Lungs, Chung-Ang Journal of Medicine 12(2):259-271 (1987).

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