Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1995-06-01
1998-02-03
Smith, Lynette F.
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
4242311, 4242341, 4241841, 424450, 530350, A61K 4505, A61K 9127, A61K 3938, C07K 100
Patent
active
057141410
ABSTRACT:
The present invention is directed to a method of improving the potency of a vaccine in a mammalian host comprising administering a therapeutically effective amount of a vaccine and a potency improving amount of IL-7. In a preferred embodiment, the IL-7 is dissolved or dispersed in a pharmaceutically acceptable carrier. The pharmaceutically acceptable carrier is preferably in the form of a lipid dispersion.
REFERENCES:
patent: 4965195 (1990-10-01), Namen et al.
Hock et al., Interleukin 7 Induces CD4.sup.+ Cell-dependent Tumor Rejection, J. Exp. Med., vol. 174, Dec. 1991, pp. 1291-1298.
Aoki et al., Expression of Murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicty in vivo, Proc. Natl. Acad. Sci. USA, vol. 89, May 1992, pp. 3850-3854.
McBride et al., Genetic Modification of a Murine Fibrosarcoma to Produce Interleukin 7 Stimulates Host Cell Infiltration and Tumor Immunity, Cancer Res., vol. 52, Jul. 1992, pp. 3931-3937.
Chazen, et al., "Interleukin 7 is a T-Cell Growth Factor", Proc. Natl. Acad. Sci., 86:5923-5927, Aug., 1989.
Grabstein, et al., "Regulation of T Cell Proliferation by IL-7", J. of Immuno., 144:3015-3020, Apr. 15, 1990.
Alderson, "Interleukin 7 Enhances Cytolytic T Lymphocyte Generation adn Induces Lymphokine-activated Killer Cells from Human Peripheral Blood", J. Exp. Med., 172:577-587, Aug. 1990.
Naylor, et al, 1982, "In vivo induction of . . . " Infection and Immunity 36(3):1209-1216.
Hickman, et al, 1990, "Regulation of human cytotoxic T . . . " J. Immunol, 145(8):2415-2420.
Ho, et al, 1992, "Liposome-formulated interleukin-2 . . . " Vaccine 10(4):209-213.
Daniel, et al, 1992, "Protective effects of a live alternated SIV Vaccine . . ." Science 258:1938-41.
Faltynek Connie Rene
Ho Rodney Jin Yong
Smith Lynette F.
University of Washington
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