Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1995-06-06
1999-09-14
Mertz, Prema
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
514 2, 514 8, 514 12, 514825, 514885, 530351, 435 6952, 4352523, 4353201, 435471, 435325, A61K 3820, C07K 1454, C12N 1524
Patent
active
059519738
ABSTRACT:
A method of treating rheumatoid arthritis comprising administering human Interleukin-4 (IL-4) to an individual afflicted with the disease. The IL-4 is administered with a pharmaceutically acceptable carrier in a dose ranging from 1 .mu.g to 100 mg.
REFERENCES:
patent: 5236705 (1993-08-01), Hamilton et al.
Howard et al., "Identification of a T Cell-Derived B Cell Growth Factor Distinct from Interleukin 2" J. Exp. Med., vol. 155, pp. 914-923 (1982).
Yoshizaki et al., "Induction of Proliferation and Ig Production in Human B Leukemic Cells by Anti-Immunoglobulins and T Cell Factors" The Journal of Immunology, vol. 128, pp. 1296-1301 (1982).
Farrar et al., "Biochemical and Physiocochemical Characterization of Mouse B Cell Growth Factor: A Lymphokine Distinct from Interleukin-2" The Journal of Immunology, vol. 131, pp. 1838-1842 (1983).
Howard et al., "Regulation of B-Cell Growth and Differentiation by Soluble Factors" Ann. Rev. Immunol., vol. 1, pp. 207-333 (1983).
Maizel et al., "Long-term Growth of Human B Cells and Their Use in a Microassay for B-Cell Growth Factor" Proc. Natl. Acad. Sci., vol. 80, pp. 5047-5051 (1983).
Okada et al., "B Cell Growth Factors and B Cell Differentiation Factor from Human T Hybridomas" J. Exp. Med., vol. 157, pp. 583-590 (1983).
Butler et al., "Characterization of Monoclonal B Cell Growth Factor (BCGF) Produced by a Human T-T Hybridoma" The Journal of Immunology, vol. 133, pp. 251-255 (1984).
Kishimoto, "Factors Affecting B-Cell Growth and Differentiation" Ann. Rev. Immunol., vol. 3, pp. 133-157 (1985).
Mehta et al., "Purification of Human B Cell Growth Factor" The Journal of Immunology, vol. 135, pp. 3298-3302 (1985).
Ohara et al., "Partial Purification of Murine B Cell Stimulatory Factor (BSF-1)" The Journal of Immunology, vol. 135, pp. 2518-2523 (1985).
Oliver et al., "B-Cell Growth Factor (B-Cell Growth Factor I or B-Cell-Stimulating Factor, Provisional 1) is a Diff. Factor for Resting B Cells . . . " Proc. Natl. Acad. Sci., vol. 82, pp. 2465-2467 (1985).
Rabin et al., "B-Cell Stimulatory Factor 1 Activates Resting B Cells" Proc. Natl. Acad. Sci., vol. 82, pp. 2935-2939 (1985).
Sideras et al., "Secretion of IgG.sub.1 Induction Factor by T Cell Clones and Hybridomas" Eur. J. Immunol., vol. 15, pp. 586-593 (1985).
Sideras et al., "Partial Biochemical Characterization of IgG.sub.1 -Inducing Factor" Eur. J. Immunol., vol. 15, pp. 593-598 (1985).
Thompson et al., "T Cell-Derived B Cell Growth Factor(s) Can Induce Stimulation of Both Resting and Activated B Cells" The Journal of Immunology, vol. 134, pp. 369-374 (1985).
Vivetta et al., "Serological, Biochemical, and Functional Identity of B Cell-Stimulatory Factor 1 and B Cell Differentiation Factor for IgG.sub.1 " J. Exp. Med., vol. 162, pp. 1726-1731 (1985).
Noma et al., "Cloning of cDNA Encoding the Murine IgG.sub.1 Induction Factor by a Novel Strategy Using SP6 Promoter" Nature, vol. 319, pp. 640-646 (1986).
Sahasrabuddhe et al., "Purification and Partial Characterization of Human Intracellular B Cell Growth Factor" Lymphokine Research, vol. 5, pp. 127-140 (1986).
O'Garra et al., Immunology Today, vol. 9, pp. 45-54 (1988).
Lewontin, ch. 3 in The Genetic Basis of Evolutionary Change.
Vogel et al., pp. 373-378 of Human Genetics.
Hunt et al., pp. 67-82 of Atlas of Protein Sequence and Structure 1972.
Sensabaugh, Isozymes, vol. 11, pp. 137-154 (1983).
Weatherall et al., Cell, vol. 16, pp. 467-479 (1979).
Nagata et al., Nature, vol. 287, pp. 401-408 (1980).
Lee et al., Proc. Natl. Acad. Sci., vol. 82, p. 4360 (1985).
Wong et al., Science, vol. 228, pp. 810-815 (1985).
Burgess et al., Blood, vol. 69, pp. 43-51 (1987).
Fuse et al., Nucleic Acids Research, vol. 12, pp. 9323-9331 (1984).
Ullrich et al., Nature, vol. 303, pp. 821-825 (1983).
Cantrell et al., Proc. Natl. Acad. Sci., vol. 82, pp. 6250-6254 (1985).
Sharma et al., Science, vol. 235, pp. 1489-1492 (1987).
Hirano et al., Nature, vol. 324, pp. 73-76 (1986).
Brandis et al., Genetic Engineering, vol. 8, pp. 299-316 (1986).
Hart et al. (1995) Immunology vol. 84 pp. 536-542.
Allen et al. (1993) J. of Immunology, vol. 151 pp. 4344-4351.
Mentz et al. (1994) J. of Biol. Chem. vol. 269, No. 33, pp. 21322-21329.
Arai Ken-ichi
Lee Frank
Mosmann Timothy
Rennick Donna
Yokota Takashi
Ching Edwin
Mertz Prema
Schering Corporation
Thampoe Immac J.
LandOfFree
Use of interleukin-4 (IL-4) to treat rheumatoid arthritis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of interleukin-4 (IL-4) to treat rheumatoid arthritis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of interleukin-4 (IL-4) to treat rheumatoid arthritis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1507913