Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-07-11
2006-07-11
Mertz, Prema (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007210
Reexamination Certificate
active
07074575
ABSTRACT:
The present invention relates to the anti-cancer activity of IL-19 polypeptide molecules. IL-19 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-19 for decreasing proliferation of ovarian cancer cells, treating ovarian cancer, amongst other uses disclosed. IL-19 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.
REFERENCES:
patent: 5985614 (1999-11-01), Rosen et al.
patent: 6583270 (2003-06-01), Rosen et al.
patent: 2002/0072089 (2002-06-01), Holtzman et al.
patent: 03/086298 (2003-10-01), None
patent: 03/087307 (2003-10-01), None
patent: 04/024894 (2004-03-01), None
Parish-Novak et al., “Interleukins 19, 20 and 24 Signal through Two Distinct Receptor Complexes,”J. Biol. Chem. 277(49):47517-47523, 2002.
Gallagher et al., “Cloning, expression and initial characterisation of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10),”Genes and Immunity 1:442-450, 2000.
Liao et al., “IL-19 Induces Production of IL-6 and TNF-α and Results in Cell Apoptosis Through TNF-α,”J. Immunol. 4288-3310, 2002.
Ghoreschi et al., “Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease,”Nature Medicine 9(1):40-46, 2003.
Chang et al., “Crystal Structure of Interleukin-19 Defines a New Subfamily of Helical Cytokines,”J. Biol. Chem. 278(5):3308-3313, 2003.
Chandrasekher Yasmin A.
McKernan Patricia A.
Mertz Prema
Walker Shelby J.
ZymoGenetics Inc.
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