Use of interleukin-1 to induce development of multipotent hemopo

Details Use of interleukin-1 to induce development of multipotent hemopo Use of interleukin-1 to induce development of multipotent hemopo

1986-07-30

1989-02-28

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530351, A61K 3700

Patent

active

048086118

ABSTRACT:
Interleukin-1, in conjunction with one or a mixture of selected colony-stimulating factors, is capable of inducing the development of primitive multipotent hemopoietic cell populations.

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Mochizuki et al., "Interleukin 1 Regulates Hematopoietic Activity, a Role Previously Ascribed to Hemopoietin 1," Proc. Natl. Acad. Sci. U.S.A. 84: 5267 (1987).
Moore and Warren, "Synergy of Interleukin 1 and Granulocyte Colony-Stimulating Factor: In Vivo Stimulation of Stem-Cell Recovery and Hematopoietic Regeneration Following 5-Fluorouracil Treatment of Mice," Proc. Natl. Acad. Sci. U.S.A. 84:7134 (1987).
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Stanley et al., "Regulation of Very Primitive, Multipotent, Hemopoietic Cells by Hemopoietin-1", Cell 45:667 (1986).
Oppenheim et al., "There Is More Than One Interleukin 1", Immunol. Today 7:45 (1986).
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