Use of interferon .gamma. for the inhibition of proliferation an

Details Use of interferon .gamma. for the inhibition of proliferation an Use of interferon .gamma. for the inhibition of proliferation an

1995-08-14

1998-09-15

Scheiner, Laurie

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

4353722, 435375, 435377, 435384, 435385, 435386, 435811, G01N 33374

Patent

active

058077448

ABSTRACT:
The invention provides a method for inhibition of proliferation of primitive hematopoietic progenitor cells and hematopoietic stem cells, by incubating preparations containing said cells with IFN-.gamma.. The method is especially useful for protecting said cells during purging techniques using cytotoxic treatment, and for protection of said cells during in vivo cytotoxic treatment.

REFERENCES:
patent: 4714680 (1987-12-01), Civin
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Brugger, W., et al., "Ex vivo Expansion of Enriched Peripheral Blood CD34.sup.+ Progenitor Cells by Stem Cell Factor, Interleukin-1.beta.. (IL-1.beta.), IL-3, Interferon-.gamma., and Erythropoietin", Blood, 81(10):2579-2584 (1993).
Richman, C.M., et al., "Interferon Protects Normal Human Granulocyte/Macrophage Colony-Forming Cells from Ara-C Cytotoxicity", Journal of Biological Response Modifiers, 9:570-575 (1990).
Rowley, S.D., and Davis, J.M., "Purging Techniques in Autologous Transplantation", Bone Marrow and Stem Cell Processing: A Manual of Current Techniques, Areman, E.M., Deeg, H.J., and Sacher, R.A. (eds.), F.A. Davis Co., Philadelphia, Pennsylvania, USA: 218-235 (1992).
Snoeck, H., et al., "Interferon-gamma and interleukin-4 reciprocally regulate the production of monocytes/macrophages and neutrophils through a direct effect on committed monopotential bone marrow progenitor cells", European Journal of Immunology, 23:1072-1077 (1993).
Snoeck, H., et al., "Differential regulation of the expression of CD38 and human leukocyte antigen-DR on CD34+ hematopoeitic progenitor cells by interleukin-4 and interferon-gamma", Experimental Hematology, 21(11):1480-1486 (1993).
Snoeck, H., et al., "Interferon-gamma is a specific inhibitor of very primitive CD34+CD38-human hematopoietic progenitor cells and not of more mature CD34+CD38+ progenitor cells", Journal of Cellular Biochemistry Supplement, 18A:15, (1994).
Snoeck, H., et al., "Regulation of myelopoiesis by interferon-gamma (IFN-gamma) and interleukin-4 (IL-4)", British Journal of Haematology, 87(1):107 (1994).
Snoeck, H.W., et al., "Interferon gamma selectively inhibits very primitive CD34++CD38-and not more mature CD34+CD38+ human hematopoietic progenitor cells", The Journal of Experimental Medicine, 180:1177-1182 (1994).

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