Use of inhibitors of the sodium-hydrogen exchanger for the produ

Details Use of inhibitors of the sodium-hydrogen exchanger for the produ Use of inhibitors of the sodium-hydrogen exchanger for the produ

1998-08-26

2000-09-05

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514256, 514396, 514406, 514415, 514438, 514461, 514895, A61K 31155, A61K 31505, A61K 31415, A61K 31405, A61K 3138

Patent

active

061143936

ABSTRACT:
Inhibitors of the sodium-hydrogen exchanger are suitable on their own or in combination with other classes of active compound for the production of a medicament for the treament of diseases which are caused by protozoa; thus of diseases which are caused by animal- and human-pathogenic protozoa, such as by intracellularly active parasites of the classes Apicomplexa and Zoomastigophorea, in particular trypanosomes, plasmodia (malaria pathogens), leishmanias, babesias and theilerias, cryptosporidiidae, sarcocystidae, amoebae, coccidia and trichomonads. NHE inhibitors are particularly preferably suitable for the production of a medicament for the treatment of tropical malaria, of tertian malaria, of quartan malaria, as well as toxoplasmosis, of coccidiosis, of intestinal sarcosporidosis, of cryptosporidosis, of Chargas' disease and of the cutaneous and visceral as well as other forms of leishmaniases; and also for the production of a medicament for the treatment of animals which have been infected by animal-pathogenic protozoa, such as by Theileria parva, the pathogen of East Coast fever of cattle, Babesia begemina, the pathogen of Texas fever in cattle and buffalo, Babesia bovis, the pathogen of European bovine babesiosis, and babesioses in dogs, cats and sheep, sarcocystidae, the pathogens of sarcocystoses in sheep, cattle and pigs, cryptosporidiidae, the pathogens of cryptosporidosis in cattle and birds, coccidia, the pathogens of coccidioses of rabbits, cattle, sheep, goats and pigs, but in particular of chickens and turkeys.

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