Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-09-29
1999-04-06
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514252, 5142225, 514258, 514259, 514263, 514267, 514303, 514311, 514386, 514392, 514443, A61K 3140
Patent
active
058919040
ABSTRACT:
The invention relates to the use of inhibitors of phosphodiesterase IV for the modulation of the motility and peristalsis of the hollow organs of the urogenital and gastrointestinal tract.
REFERENCES:
"Cyclic Nucleotide Phosphodiesterase (PDE) Isoenzymes is the Human Detrusor Smooth Muscle," M.C. Truss et al., Urol Res (1996) Springer-Verlag pp. 129-134.
"Cyclic Nucleotide Phosphodiesterase in Human Cavernous Smooth Muscle," A. Taber et al., World J Urol 1997 Springer-Verlag 1997, pp. 32-35.
"Analysis of PDE Isoenzyme Profiles in Cells and Tissues by Pharmacological Methods," Hermann Tenor and Christian Schudt. Phosphodiesterase Inhibitors (1996) pp. 21-23; and 34.
"Phosphodiesterase Isoenzymes in Human Ureteral Smooth Muscle: Identification, Characterization, and Functional Effects of Various Phosphodiesterase Inhibitors in Vitro," Stief Urol Int. (1995) pp 183-189.
Goodman et al, Pharmacological Basis of Therapeutics, p. 735, 1975.
Giembycz et al, Biochemical Pharmacology, vol. 42 No. 3 pp. 663-677, 1991.
Dorland's Illustrated Medical Dictionary, 24th edition, p. 952, 1965.
Embase 91222422, 1991.
Nicholson et al, Trends in Pharmacological Sciences, vol. 12, No. 1, Jan. 1991.
Goodman et al, Pharmacological Basis of Therapeutics, p. 375, 1975.
Forssmann Wolf-Georg
Meyer Markus
Schulz-Knappe Peter
Stief Christian
Strohmeyer Torsten
Cook Rebecca
Forssmann Wolf-Georg
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