Use of in vitro assay techniques to measure parameters related t

Details Use of in vitro assay techniques to measure parameters related t Use of in vitro assay techniques to measure parameters related t

1983-06-16

1986-09-09

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

424101, 435 4, 435 29, 435 7, 436811, A61K 3514, A61K 3900, C12Q 102

Patent

active

046108785

ABSTRACT:
Described herein are methods for quantifying in vitro various parameters related to the use of transfer factor (e.g., dialyzable leukocyte extract containing transfer factor) in the therapeutic and/or prophylactic treatment of patients having antigen-selective defects in cell mediated immunity, so as to standardize such parameters, predict or estimate therefrom the effectiveness of such treatment in vivo, determine optimum dosages and/or administrative regimens therefor and monitor the progress of patients receiving such treatment.
In one embodiment of the invention, the quantification of the various parameters is based upon in vitro assays which measure mediators of cellular immunity produced and released by appropriate leukocytes (e.g., those of the patient before treatment, those of potential donors, those of target cells, those of the patient after treatment with transfer factor, and the like) sensitized to a specific antigen. In another embodiment of the invention the in vitro assays employed are those which provide a measure of tumor-antigen specific cytotoxicity mediated by T cells, i.e., a measure of the increase in activity or number of cytotoxic T cells specific for tumor antigens.

REFERENCES:
patent: 3988115 (1976-10-01), Modabber
patent: 4124701 (1978-11-01), Bach et al.
patent: 4284412 (1981-08-01), Hansen et al.
Natelson et al--Clinical Immunochemistry (1978) (article by Fudenberg), pp. 228, 232, 233, 237-238, 241 and 248.
Wilson et al--Lymphokines, vol. 4 (1981), pp. 107-173.
Bach--Immunology (1982), pp. 376-378 (Pub. John Wiley).

Affiliated with

Also associated with

Rating

Use of in vitro assay techniques to measure parameters related t does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of in vitro assay techniques to measure parameters related t, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of in vitro assay techniques to measure parameters related t will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1014861