Use of imidazopyrazole derivatives as analgesics and anti-inflam

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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5483031, A61K 31415, C07D23500

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active

052329399

ABSTRACT:
Compounds of formula (I): ##STR1## and pharmaceutically acceptable salts thereof are analgesics and anti-inflammatory agents as well having anti-ulcer and 5-lipoxygenase inhibitory activities.

REFERENCES:
patent: 4500630 (1985-02-01), Sato et al.
patent: 4788134 (1988-11-01), Ozaki et al.
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Bulletin de la Societe Chimique de France, Nos. 1-2, 1975, pp. 255-256, Paris, FR; J. Elguero et al.: "Systemes aromatiques a 10 electrons eta derives de l'aza-3a pentalene. XIX.-Recherches dan la serie dihydro-2,3 imidazo[1,2-b]pyrazole" *p. 256, 1b*.
Journal of Organic Chemistry, vol. 49, No. 19, 1984, pp. 3534-3540, Washington, DC, US; S. G. Wood et al.: "Synthesis and structural studies of certain novel imidazo[1,2-b]pyrazole nucleosides" *p. 3534, compound 3; p. 3538, compound 3*.
Chemical Abstracts, vol. 95, No. 5, 1981, p. 32, column 2, abstract No. 35305s, Columbus, Ohio, US; A. Sato et al.: "Evaluation of combinations of drugs that inhibit Ehrlich tumor cell ribonucleotide reductase", & Cancer Res. 1981, 41(5), 1637-41 *Pyrazolomididazole*.
Japanese Patents Gazette, week 8724, Jul. 29, 1987, section Ch, class G, p. 4, accession No. 87-165911/24, Derwent Publications Ltd., London, GB; & JP-A-62 096 940 (Fuji Photo Film K.K.) Jun. 5, 1987, & US-A-4 788 134 (H. Ozaki et al.) Nov. 29, 1988.

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