Use of imidazopyrazole derivatives as analgesics and anti-inflam

Details Use of imidazopyrazole derivatives as analgesics and anti-inflam Use of imidazopyrazole derivatives as analgesics and anti-inflam

1992-11-13

1994-10-11

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483031, A61K 31415

Patent

active

053547683

ABSTRACT:
Compounds of formula (I): ##STR1## [in which: R.sup.1 and R.sup.2 are hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, aralkyl, arylalkenyl, aryl, aromatic heterocyclic, cyano or halogen; R.sup.3 is hydrogen, optionally substituted alkyl, aralkyl or acyl; R.sup.4 and R.sup.5 are hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, aralkyl, arylalkenyl, aryl or aromatic heterocyclic]; and pharmaceutically acceptable salts thereof are analgesics and anti-inflammatory agents as well having anti-ulcer and 5-lipoxygenase inhibitory activities.

REFERENCES:
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patent: 4639415 (1987-01-01), Kaneko et al.
patent: 4719218 (1988-01-01), Bender et al.
patent: 4752561 (1988-06-01), Nishiyima et al.
patent: 4788134 (1988-11-01), Ozaki et al.
patent: 5232939 (1993-08-01), Terada et al.
Chemical Abstracts, vol. 82, No. 6, Abstract 42, 451w, Feb. 10, 1973, p. 363.
Chemical Abstracts, vol. 82, No. 22, Abstract 156174p, Jun. 2, 1975, p. 597.

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