Use of IL-4 for inhibition of the breakdown of articular cartila

Details Use of IL-4 for inhibition of the breakdown of articular cartila Use of IL-4 for inhibition of the breakdown of articular cartila

1994-05-12

1997-10-21

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 851, 514 12, 514825, A61K 3820, C07K 1400

Patent

active

056793383

ABSTRACT:
Applicants' invention discloses therapeutic compositions and methods for treating articular cartilage breakdown associated with osteoarthritis and rheumatoid arthritis. The compositions comprise a therapeutically effective amount of IL-4 to reduce or inhibit breakdown of articular cartilage, optionally in the presence of a pharmaceutically acceptable carrier or excipient. Methods for treating articular cartilage breakdown comprise administering a therapeutically effective amount of IL-4 to reduce or inhibit breakdown of articular cartilage, optionally in the presence of a pharmaceutically acceptable carrier to a subject in need of such treatment. The invention also relates to compositions and methods for treating tumor metastases, periodontal disease, emphysema and osteoporosis.

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van Roon et al: Inhibiton of RA synovial flluid mononuclear cell-induced cartliage damage by interleukin-4. Arthritis & Rheumatism, vol. 36 (supplement), 1993, p. s154 (abstract number B78).
Interleukin Receptor--Targeted Molecules for Treatment of Inflammatory Arthritis, CA118(5):329-36F.
IL-4 and Interleukin-1 Beta synergistically induced VCAM-1 CA116(21):212855W.
Synergistic anti-inflammatory compositions containing interleukin-4, CAA115(6):166651f.
Interleukin-4 in method and compostions for degradation and prevention of fibrin deposits associated with pathological conditions, CA114(3):22375a.
Zlotnik, A. et al., Evidence for effects of IL-4 (B cell Stimulatory Factor 1) on macrophages: Enhancement of Antigen Presenting Ability of Bone Marrow Deried Macrophages, J. Immunol., 138:4275-4279 (1987).

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