Use of IL-2 receptor-targeted therapeutics to inhibit allograft

Details Use of IL-2 receptor-targeted therapeutics to inhibit allograft Use of IL-2 receptor-targeted therapeutics to inhibit allograft

1997-11-21

2000-09-05

Fitzgerald, David L.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241821, 4241831, 424 852, 424 851, 4241451, 4241441, 4241341, 4241731, 42419711, 42419511, 4241541, A61K 3820, A61K 39395

Patent

active

061139009

ABSTRACT:
Methods of inhibiting allograft rejection and of inhibiting B lymphocyte-mediated autoimmune diseases are provided. The methods involve the use of agents specific for the IL-2 receptor, such as monoclonal antibodies or IL-2, optionally linked to a cytotoxin. Administration of the agents inhibits the proliferation of lymphocytes expressing the IL-2 receptor and thus mitigates unwanted immune responses.

REFERENCES:
patent: 4359457 (1982-11-01), Neville et al.
patent: 4388309 (1983-06-01), Fabricius
patent: 4440747 (1984-04-01), Neville
patent: 4443427 (1984-04-01), Reinherz et al.
patent: 4489710 (1984-12-01), Spitler
patent: 4520226 (1985-05-01), Neville et al.
patent: 4545985 (1985-10-01), Pastan
patent: 4550086 (1985-10-01), Reinherz et al.
patent: 4675382 (1987-06-01), Murphy
patent: 4677061 (1987-06-01), Rose et al.
patent: 4908433 (1990-03-01), Mertelsmann
patent: 4946674 (1990-08-01), von Eichborn et al.
patent: 5011684 (1991-04-01), Strom
patent: 5080898 (1992-01-01), Murphy
patent: 5336489 (1994-08-01), Strom
patent: 5510105 (1996-04-01), Strom
patent: 5587162 (1996-12-01), Strom
patent: 5607675 (1997-03-01), Strom
patent: 5674494 (1997-10-01), Strom
patent: 5916559 (1999-06-01), Strom

Affiliated with

Also associated with

Rating

Use of IL-2 receptor-targeted therapeutics to inhibit allograft does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of IL-2 receptor-targeted therapeutics to inhibit allograft , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of IL-2 receptor-targeted therapeutics to inhibit allograft will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2209188