Use of IL-13 to induce 15-lipoxygenase

Details Use of IL-13 to induce 15-lipoxygenase Use of IL-13 to induce 15-lipoxygenase

1995-05-19

1998-11-03

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

514 12, 514 21, A61K 3820

Patent

active

058304533

ABSTRACT:
Methods are disclosed for inducing the production of 15-lipoxygenase (15-LO) in animal or human cells comprising monocytes via the administration of Interleukin 13 (IL-13). These methods are effective in therapy of inflammatory conditions responsive to products of 15-LO activity, including 15-s-hydroxyeicoiatetraenoic (15-S-HETE) and Lipoxin A.sub.4 (LXA.sub.4). Such administration directs intervention to specific and effectors of inflammation, rather than the current methods of symptomatic treatment.

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