Use of IL-1 antagonists to treat gout

Drug – bio-affecting and body treating compositions – Lymphokine

Reexamination Certificate

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C424S094400, C514S002600, C514S404000, C514S469000

Reexamination Certificate

active

07820154

ABSTRACT:
Methods of treating, inhibiting, or ameliorating gout, including chronic acute (refractory) gout, pseudogout, or drug-induced gout, in a human subject in need thereof, comprising administering to a subject in need a therapeutic amount of an interleukin 1 (IL-1) antagonist, wherein the incidence of a gout flare is reduced or inhibited.

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patent: WO 2006/084145 (2006-08-01), None
patent: WO 2007/077042 (2007-07-01), None
patent: WO 2007/077261 (2007-07-01), None
Martinon, 2006, “Gout-associated uric acid crystals activate the NALP3 inflammasome,” Nature 440:237-241 (Nature Publishing Group, London, UK).
Gabay, 2003, “IL-1 Trap,” Curr. Opin. Invest. Drugs 4:593-597 (Thompson Reuters, Philadelphia, PA).
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