Use of hyperimmune milk to prevent suppression of T-lymphocyte p

Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Milk or colostrum

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4241501, 4242781, 514878, D61K 4500

Patent

active

060569786

ABSTRACT:
The invention relates to the use of hyperimmune milk derived from milk producing animals hyperimmunized with bacterial antigens including intestinal bacteria. The present hyperimmune milk effectively prevents the decline of immunological functions observed in aging or immunocompromised animals and prevents the translocation of indigenous enteric bacteria from the GI tract of immunocompromised or aged animals, thereby preventing indigenous infection. More specifically, the present hyperimmune milk is administered to an animal in an amount sufficient to effectively prevent translocation of indigenous enteric bacteria in, delay the onset of, lower the rate of, or restore the declining immune functions of, aging or otherwise immunocompromised animals.

REFERENCES:
patent: 4879110 (1989-11-01), Beck et al.
patent: 5106618 (1992-04-01), Beck et al.
Ishida et al., "Consumption of Milk from Cows Immunized with Intestinal Bacteria Influences Age Related Changes in Immune Conpetence in Mice," Journal of Nutrition, 122:1875-1883, published Sep. 1992.
Murasaki et al., "Influence of Intake of Skim Milk from Cows Immunized with Intestinal Bacterial Antigens on Onset of Renal Disease in (NZBX NZW)F, Mice Fed Ad Libitum or Restricted in Energy Intake," Journal of Nutrition, 121:1860-1868, published Nov. 1991.
Murosaki et al 1991 121:1860.
Golay et al 1990 J Clin Nutr. 1014.
Adler, W. et al., Effect of age upon primary alloantigen recognition by mouse spleen cells, J. Immunol. 107(5):1357-1362 (1971).
Berg, R., Translocation of indigenous bacteria from the intestinal tract, Human Intestinal microflora in Health and Disease, Chapter 15:333-352 (1983).
Bocci, V., Production and role of interferon in physiological conditions, Biol. Rev. 56:49-85 (1981).
Chandra, R., Nutritional regulation of immunity and risk of infection in old age, Immunol. 67:141-147 (1989).
Gabrielsen, A. et al., Suppression of murine lupus eryhtematosus by Dactinomycin, Nature 264:439-440 (Dec. 1976).
Golay, A. et al., Cholesterol-lowering effect of skim milk from immunized cows in hypercholesterolemic patients, Am. J. Clin. Nutr. 52:1014-1019 (1990).
Hilpert H. et al., Use of bovine milk concentrate containing antibody to rotavirus to treat rotavirus gastroenteritis in infants, J. Infect. Dis. 156(1):158-166 (Jul. 1987).
Hirokawa K. et al., Influence of age of thymic grafts on the differentiation of T cells in nude mice, Clin. Immunol. & Immunopathol. 24:251-262 (1982).
Janeway, C., Frontiers of the immune system, Nature 333:804-806 (Jun. 1988).
Kato K. et al., Qualitative and quantitative analysis of autoantibody production in aging mice, Aging Immunol. Inf. Dis. 1(3):177-190 (1988).
Kubo C. et al., Calorie source, calorie restriction, immunity and aging of (NZB/NZW)F1, mice, J. Nutr. 114:1884-1899 (1984).
Makinodan T. et al., Age influence on the immune system, Adv. Immunol. 29:287-330 (1980).
Mastromarino, A., Antibiotic radioprotection of mice exposed to supralethal whole-body irradiation, Radiation Research 68:329-338 (1976).
Miake S. et al., Protective effect of Lactobacillus casei on Pseudomonas aeruginosa infection in mice, Infect. Immun. 48(2):480-485 (May 1985).
Nomoto K. et al., Augmentation of host resistance to Listeria monocytogenesis infection by Lactobacillus casei, J. Clin. Lab. Immunol. 17:91-97 (1985).
Price G. et al., Immunologic deficiencies in senescence II. Characterization of extrinsic deficiencies, J. Immunol. 108(2):413-417 (Feb. 1972).
Tacket C. et al., Protection by milk immumoglobulin concentrate against oral challenge with enterotoxigenic Escherichia coli, N. Engl. J. Med. 318(19):1240-1243 (May 1988).
Wade A. et al., Aging, idiotype repertoire shifts, and compartmentalization of the mucosal-associated lymphoid system, Adv. Immunol. 36:143-188 (1984).
Waldmann, T., Monoclonal Antibodies in Diagnosis and Therapy, Science 252:1657-1662 (Jun. 1991).
Welsh, J., et al., Anti-infective properties of breast milk, J. Pediatr., 94(1):1-9 (Jan. 1979).
Yoshikai Y. et al., Increased susceptibility to Escherichia coli infection in mice pretreated with Corynebacterium parvum, Microbiol. Immunol. 27(3):273-282 (1983).
Ishida et al., "The Defence Effect of the Immunized Milk on the Lowered Immune Function Brought About by Ageing," Abstract No. 20p9, Annual Meeting of Japan Society for Bioscience, Biotechnology and Agrochemistry at Ritsumeikan University, Kyoto, Mar. 1991.
Dialog 351, WPI Accession No. 92-288888/199235, English language abstract of JP 4198136 A. 1992.
English language translation of Japanese Patent No. Hei 2(1990)-331861 1992.
Ishida, A. et al., "Administration of milk from cows immunized with intestinal bacteria protects mice from radiation-induced lethality," Biotherapy 5:215-225 (1992).
Yoshikai, Y. et al., "Sequential appearance of T-cell receptor .gamma..delta.- and .alpha..beta.-bearing intestinal intra-epithelial lymphocytes in mice after irradiation," Immunol. 74:583-588 (1991).
Murosaki, S. et al., "Failure of T cell receptor V.sub..beta. negative selection in murine intestinal intra-epithelial lymphocytes," Intl. Immunol. 3(10):1005-1013 (1991).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of hyperimmune milk to prevent suppression of T-lymphocyte p does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of hyperimmune milk to prevent suppression of T-lymphocyte p, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of hyperimmune milk to prevent suppression of T-lymphocyte p will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1592067

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.