Use of hydroxyethyl starch for improvement of microcirculation

Details Use of hydroxyethyl starch for improvement of microcirculation Use of hydroxyethyl starch for improvement of microcirculation

1994-03-30

1996-03-26

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514832, 514833, 536111, A61K 3172, A61K 3170, C08B 3110

Patent

active

055020437

ABSTRACT:
The use of a hydroxyethyl starch specification with a molecular weight M.sub.W of 110,000 to 150,000, a substitution level MS of 0.38 to 0.5, a substitution level DS of 0.32 to 0.45, and a C.sub.2 /C.sub.6 ratio from 8 to 20 for improvement of microcirculation in a peripheral arterial circulation disorder, in particular in already existing peripheral arterial occlusive disease in Stage II according to Fontaine. This hydroxyethyl starch specification can be used in suitable concentrations, e.g., as 6 wt.-% or 10 wt.-% solution, whereby these solutions optionally contain conventional adjuvants and additives.

REFERENCES:
Infusionstherapie, Bd. 17, Nr. 2, 1990 Seiten 79--82, Kortsik, C. F. et al. "Konjunktivaler Sauerstoffpartialdruk, Hamorheologie Und Krieslaufparameter Bei Akutem Zerebralem Insult Vor Und Nach Infusion Von 6Prozentiger Niedermolkularer Hydroxyathylstarke".
Arzneimittelforschung, Bd. 43(10, Nr. 2, 1993 Seiten 99--105, Jung, F. et al. "Einfluss Der Molekulstruktur Von Hydroxyathylstarke Aug Die Eliminationskinetik Und Die Fliessfahigkeit Des Blutes Bei Probanden".
Arzneimittelforschung, Bd. 41, Nr. 5, 1991 Seiten 494--498 Weidler, B. et al. "Pharmakinetische Merkmale Als Kriterien Fur Den Klinischen Einsatz Von Hydroxyathylstarke".
Lutz, H. and Hartung, H. J., "State of Investigations on Hydroxyethylstarch".
Ehrly, A. M. et al., "Verbesserung der FlieBeigenschaften des Blutes nach Infusion von niedermolekularer Hydroxya/ thylsta/ ke (Expafusin.COPYRGT.) bei gesunden Probanden", Infusiontherapie, 6:331-336 (1979).

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