Use of hydrophobic interaction chromatography to purify polyethy

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – From heterocyclic reactant containing as ring atoms oxygen,...

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2101982, 210656, B01D 1506

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active

057476390

ABSTRACT:
The present invention relates to a process for purifying polyethylene glycols (PEGs) which utilizes hydrophobic interaction chromatography (HIC) to separate the PEGs based on their size and on their end-group functionality. The purified PEGs can be used to modify biologically active molecules and improve overall production of such molecules.

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Trathnigg et al, "Analysis of Polyethers by Isocratic HPL with Universal Detectors. I. Optimization of Chromatographic Conditions", Journal of Liquid Chromatography,16(12): 2439-2452 (1992).
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