Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1998-09-28
2000-11-07
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514724, A61K 31135, A61K 31045
Patent
active
06143793&
ABSTRACT:
The hydrophilic penetration agents customarily used for the transcutaneous penetration of active ingredients are, surprisingly, found to improve the penetration of antifungal agents through the nails. A corresponding dermatological composition contains at least one antifungal agent chosen, in particular, from among those of the allylamine family, such as terbinafine-HCl and naftifine-HCl; at least one hydrophilic penetration agent chosen, in particular, from among the glycols, glycol monoethers, glycol diethers, dimethylsulphoxide, caprolactam, dimethylisosorbide, isopropylidene glycerol, dimethylimidazolidinone, ethyl lactate, the polyoxyethylenated C.sub.8 -C.sub.10 glycerides, polyethylene glycol 20 glyceryl laurate and dimethylacetamide; and a water-alcohol solvent medium which dissolves the said antifungal agent(s) and in which the said penetration agent(s) is (or are) at least partially miscible.
REFERENCES:
patent: 4470962 (1984-09-01), Keith et al.
patent: 4859696 (1989-08-01), Kamiya et al.
patent: 4886545 (1989-12-01), Peck et al.
patent: 4920112 (1990-04-01), Onishi
patent: 4946870 (1990-08-01), Partain, III
patent: 5053227 (1991-10-01), Chiang et al.
patent: 5116603 (1992-05-01), Friedman
patent: 5181914 (1993-01-01), Zook
patent: 5215520 (1993-06-01), Schroot
patent: 5256647 (1993-10-01), Minaskanian
patent: 5264206 (1993-11-01), Bohn et al.
patent: 5661170 (1997-08-01), Chodosh
patent: 5814305 (1998-09-01), Laugier et al.
patent: 5827870 (1998-10-01), Chodosh
JP 61-151117 -Abstract -Bayer Yakuhin K.K., vol. 10, No. 350 1986.
JP 60-58914 A -Abstract -Shionogi Seiyaku K.K. -vol. 9, No. 188 -1985.
Laugier Jean-Pierre
Rigenbach Francois
Rude Marie-France
Touzan Philippe
Loeschorn Carol A.
Novartis AG
Weddington Kevin E.
LandOfFree
Use of hydrophilic penetration agents in dermatological composit does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of hydrophilic penetration agents in dermatological composit, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of hydrophilic penetration agents in dermatological composit will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1641660