Use of hydrophilic penetration agents in dermatological composit

Details Use of hydrophilic penetration agents in dermatological composit Use of hydrophilic penetration agents in dermatological composit

1995-01-30

1998-09-29

Gardner-Lane, Sally

Drug, bio-affecting and body treating compositions

Manicure or pedicure compositions

514858, 514947, H61K 704, H61K 7043

Patent

active

058143050

ABSTRACT:
The hydrophilic penetration agents customarily used for the transcutaneous penetration of active ingredients are, surprisingly, found to improve the penetration of antifungal agents through the nails. A corresponding dermatological composition contains at least one antifungal agent chosen, in particular, from among those of the allylamine family, such as terbinafine-HCl and naftifine-HCl; at least one hydrophilic penetration agent chosen, in particular, from among the glycols, glycol monoethers, glycol diethers, dimethylsulphoxide, caprolactam, dimethylisosorbide, isopropylidene glycerol, dimethylimidazolidinone, ethyl lactate, the polyoxyethylenated C.sub.8 -C.sub.10 glycerides, polyethylene glycol 20 glyceryl laurate and dimethylacetamide; and a water-alcohol solvent medium which dissolves the said antifungal agent(s) and in which the said penetration agent(s) is (or are) at least partially miscible.

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