Use of hyaluronic acid as an immunosuppressant

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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A01N 4304

Patent

active

060136413

ABSTRACT:
A pharmaceutical formulation of hyaluronic acid is administered to a patient suffering from undesirable T cellactivity. The hyaluronic acid inhibits T cell activity at doses that are well-tolerated by the recipient. Conditions suitable for treatment include graft vs. host disease, graft rejection and certain autoimmune diseases having a T cell component.

REFERENCES:
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Lesley, J. et al., "Hyaluronan Binding Function of CD44 is Transiently Activated on T Cells During an In Vivo Immune Response," J. Exp. Med., 180:383-387 (1994).
Kimura, K. et al., "Role of Glycosaminoglycans in the Regulation of T Cell Proliferation Induced by Thymic Stroma-Derived T Cell Growth Factor," The Journal of Immunology, 146:2618-2624 (1991).
Galdandrini, R. et al., "Hyaluronate is Costimulatory for Human T Cell Effector Functions and Binds to CD44 on Activated T Cells," The Journal of Immunology, 153:21-31 (1994).
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