Use of hyaluronic acid and corresponding salts for the preparati

Details Use of hyaluronic acid and corresponding salts for the preparati Use of hyaluronic acid and corresponding salts for the preparati

1998-04-28

1999-10-26

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

A61K 31715

Patent

active

059729090

ABSTRACT:
Described herein is the use of hyaluronic acid for intra-articular irrigation, in the form of an aqueous solution, comprising hyaluronic acid having molecular weight of between 1.8 and 2.2 million daltons, or one of its pharmaceutically acceptable salts, in a concentration of between approximately 0.1% and approximately 0.9% weight/volume, and one or more cationic species chosen from among sodium, potassium, calcium and magnesium, and one or more anionic species chosen from among chloride ions, phosphate ions and citrate ions.

REFERENCES:
patent: 4141973 (1979-02-01), Balazs
patent: 5409904 (1995-04-01), Hecht et al.
The Journal of Rheumatology, 19:5, pp. 772-779 (1992), "Tidal Irrigation Versus Conservative Medical Management in Patients with Osteoarthritis of the Knee: A Prospective Randomized Study", Robert W. Ike et al.
The Journal of Bone and Joint Surgery, vol. 76-B, No. 3, (May 1994), "The Effect in Vitro of Irrigating Solutions on Intact Rat Articular Cartilage", S. K. Bulstra et al.

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