Use of human transferrin in controlling insulin levels

Details Use of human transferrin in controlling insulin levels Use of human transferrin in controlling insulin levels

1998-10-07

2000-05-30

Kemmerer, Elizabeth

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Processes of preparing a desired or intentional composition...

4241391, 4241411, 435 71, A61K 3800, A61K 3816, A61K 3845, A61K 39395, G01N 3353

Patent

active

06069193&

ABSTRACT:
The present invention relates to the use of transferrin in controlling insulin levels. Transferrin can disrupt insulin:receptor interactions in mammalian cells, may be used in mammals to treat hypoglycemia, may also be used to inhibit production of insulin by mammalian cells, and can decrease the serum insulin levels in a mammal. The invention further provides methods for identifying compounds which modulate the effect of transferrin on insulin signal transduction. Pharmaceutical compositions containing transferrin are also disclosed.

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Ishibashi, F., "Glomerular Clearance and Tubular Reabsorption of Transferrin Microtransferrinuric Patients with Non-insulin-Dependent Diabetes," Diabetes Research and Clinical Practice, 25(3):169-75 (1994).
Fagerberg, et al., "Carbohydrate-Deficient Transferrin is Associated with Insulin Sensitivity in Hypertensive Men," J. Clin. Endocrin.& Metab., 79(3):712-15 (1994).
Schaefer et al., "A New Transgenic Mouse Model of Chronic Hyperglycemia," Diabetes, 43:143-53 (1994).

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