Use of human transferrin in controlling insulin levels

Details Use of human transferrin in controlling insulin levels Use of human transferrin in controlling insulin levels

1996-01-11

1998-12-15

Walsh, Stephen

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Binds antigen or epitope whose amino acid sequence is...

4241411, 435 71, 514 2, A61K 39395, G01N 3353

Patent

active

058492933

ABSTRACT:
The present invention relates to the use of transferrin in controlling insulin levels. Transferrin can disrupt insulin:receptor interactions in mammalian cells, may be used in mammals to treat hypoglycemia, may also be used to inhibit production of insulin by mammalian cells, and can decrease the serum insulin levels in a mammal. The invention further provides methods for identifying compounds which modulate the effect of transferrin on insulin signal transduction. Pharmaceutical compositions containing transferrin are also disclosed.

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Fagerberg, et al., "Carbohydrate-Deficient Transferrin is Associated with Insulin Sensitivity in Hypertensive Men," J. Clin. Endocrin. & Metab., 79(3):712-15 (1994).
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